Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus.
A. S. Sokolova,A. S. Sokolova,Olga I. Yarovaya,Olga I. Yarovaya,M. D. Semenova,Anna A. Shtro,Iana R. Orshanskaya,Vladimir V. Zarubaev,Nariman F. Salakhutdinov,Nariman F. Salakhutdinov +9 more
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TLDR
The design and synthesis of a series of novel heterocyclic derivatives of (–)-borneol and (–-isoborneol as potent inhibitors of the influenza A virus are presented.Abstract:
Herein, we present the design and synthesis of a series of novel heterocyclic derivatives of (-)-borneol and (-)-isoborneol as potent inhibitors of the influenza A virus. All compounds were tested for their toxicity against MDCK cells and for virus-inhibiting activity against the influenza virus A/Puerto Rico/8/34 (H1N1). Compounds 7, 16 and 26 containing a morpholine fragment exhibited the highest efficiency as agents inhibiting the replication of the influenza virus A(H1N1) with selectivity indices of 82, 45 and 65, correspondingly. Derivatives 9 (SI = 23) and 18 (SI = 25) containing a 1-methylpiperazine motif showed moderate antiviral activity. Structure-activity analysis of this new series of borneol derivatives revealed that a 1,7,7-trimethylbicyclo[2.2.1]heptan scaffold is required for the antiviral activity.read more
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Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials
Shokoh Parham,Anousheh Zargar Kharazi,Hamid Reza Bakhsheshi-Rad,Hamid Reza Bakhsheshi-Rad,Hadi Nur,Ahmad Fauzi Ismail,Safian Sharif,Seeram Ramakrishna,Filippo Berto +8 more
TL;DR: In this paper, the authors highlight the antibacterial, antiviral, and radical scavenger (antioxidant) properties of herbal materials, including clove, portulaca, tribulus, eryngium, cinnamon, turmeric, ginger, thyme, pennyroyal, mint, fennel, chamomile, burdock, eucalyptus, primrose, lemon balm, mallow, and garlic.
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Monoterpenes and Their Derivatives-Recent Development in Biological and Medical Applications.
TL;DR: This review focuses on selected aliphatic, monocyclic, and bicyclic monoterpenes like geraniol, thymol, myrtenal, pinene, camphor, borneol, and their modified structures and the introduction of various functionalized moieties into the molecules in question.
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Potential anti-influenza effective plants used in Turkish folk medicine: A review
TL;DR: Thirty-nine plants have been confirmed in the recent experimental anti-influenza research, which strongly shows that these plants are a rich pharmacological source.
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Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (-)-Borneol from Abies sibirica and (+)-Camphor.
A. S. Sokolova,Olga I. Yarovaya,Olga I. Yarovaya,N. I. Bormotov,Larisa N. Shishkina,Nariman F. Salakhutdinov,Nariman F. Salakhutdinov +6 more
TL;DR: The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N‐heterocycle, such as morpholine or 4‐methylpiperidine, and a 1,7,7‐trimethylbicyclo[2.1]heptane scaffold was favorable for antiviral activity.
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Synthesis of Camphecene and Cytisine Conjugates Using Click Chemistry Methodology and Study of Their Antiviral Activity.
Oleg I. Artyushin,Aleksandra A. Moiseeva,Vladimir V. Zarubaev,Aleksander V. Slita,Anastasiya V Galochkina,Anna A. Muryleva,Sophia S. Borisevich,Olga I. Yarovaya,Olga I. Yarovaya,Nariman F. Salakhutdinov,Nariman F. Salakhutdinov,Valery K. Brel +11 more
TL;DR: It has been shown that the antiviral activity is affected by the length and nature of linkers between cytisine and camphor units and the lead compound 13 can be explained by its influence on the functioning of neuraminidase.
References
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