N
Nina I. Komarova
Researcher at Russian Academy of Sciences
Publications - 58
Citations - 698
Nina I. Komarova is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Catalysis & Oligonucleotide. The author has an hindex of 14, co-authored 54 publications receiving 583 citations.
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Journal ArticleDOI
Anti-viral activity of (-)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009.
Dmitriy N. Sokolov,Vladimir V. Zarubaev,Anna A. Shtro,Marina P. Polovinka,Olga A. Luzina,Nina I. Komarova,Nariman F. Salakhutdinov,Oleg I. Kiselev +7 more
TL;DR: In this article, the antiviral activity of usnic acid and its derivatives against the pandemic influenza virus A(H1N1)pdm09 was studied for the first time, and a total of 26 compounds representing (+) and (-) isomers of usnik acid and their derivates were tested for cytotoxicity and anti-viral activity in MDCK cells by microtetrazolium test and virus yield assay, respectively.
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Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.
Alexandra L. Zakharenko,T. M. Khomenko,T. M. Khomenko,Svetlana Zhukova,Olga A. Koval,Olga A. Koval,Olga D. Zakharova,Rashid O. Anarbaev,Rashid O. Anarbaev,Natalya Sh. Lebedeva,Natalya Sh. Lebedeva,Dina V. Korchagina,Nina I. Komarova,Vladimir Vasiliev,Jóhannes Reynisson,Konstantin P. Volcho,Konstantin P. Volcho,Nariman F. Salakhutdinov,Nariman F. Salakhutdinov,Olga I. Lavrik,Olga I. Lavrik +20 more
TL;DR: The study of cytotoxicity of these compounds revealed that all compounds cause an apoptotic cell death in MCF-7 and Hep G2 cells, therefore the new class of very effective inhibitors of TDP1 was elaborated.
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5′-bis-pyrenylated oligonucleotides displaying excimer fluorescence provide sensitive probes of RNA sequence and structure
Elena V. Kostenko,Mikhail Dobrikov,Dmitrii V. Pyshnyi,Vladislav A. Petyuk,Nina I. Komarova,Valentin V. Vlassov,Marina A. Zenkova +6 more
TL;DR: The 5'-bis-pyrenylated oligon nucleotides have been successfully used for investigation of affinity and kinetics of antisense oligonucleotides binding to the multidrug resistance gene 1 (PGY1/MDR1) mRNA.
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Synthesis and activity of (+)-usnic acid and (−)-usnic acid derivatives containing 1,3-thiazole cycle against Mycobacterium tuberculosis
Olga B. Bekker,D. N. Sokolov,Olga A. Luzina,Nina I. Komarova,Yuriy V. Gatilov,Sofia Andreevskaya,Tatiana Smirnova,D. A. Maslov,Larisa Chernousova,Nariman F. Salakhutdinov,Valery N. Danilenko +10 more
TL;DR: The results demonstrate that the dextrorotatory isomer (+)-3 leads to the lysis of intact macrophages to a degree higher than that obtained spontaneously and significantly higherthan that obtained with the levorotatoryis isomer.
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Oligonucleotides complementary to a promoter over the region -8...+2 as transcription primers for E. coli RNA polymerase.
M.A. Grachev,Evgeny Zaychikov,E.M. Ivanova,Nina I. Komarova,I.V. Kutyavin,N.P. Sidelnikova,I.P. Frolova +6 more
TL;DR: Primer-dependent transcription by E. coli RNA polymerase on T7 promoter A2 has been studied and synthetic deoxyribonucleotides complementary to the promoter over the region -8...+2 were taken as primers.