A
Anna Maria Calcagno
Researcher at National Institutes of Health
Publications - 31
Citations - 4955
Anna Maria Calcagno is an academic researcher from National Institutes of Health. The author has contributed to research in topics: ATP-binding cassette transporter & Cancer. The author has an hindex of 19, co-authored 31 publications receiving 4595 citations. Previous affiliations of Anna Maria Calcagno include United States Department of Health and Human Services & University of Kansas.
Papers
More filters
Journal ArticleDOI
A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity
Chava Kimchi-Sarfaty,Jung Mi Oh,In-Wha Kim,Zuben E. Sauna,Anna Maria Calcagno,Suresh V. Ambudkar,Michael M. Gottesman +6 more
TL;DR: It is hypothesized that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites.
Journal ArticleDOI
Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics
Mollie H. Wright,Anna Maria Calcagno,Crystal D. Salcido,Marisa D Carlson,Suresh V. Ambudkar,Lyuba Varticovski +5 more
TL;DR: Brca1-deficient mouse mammary tumors harbor heterogeneous cancer stem cell populations, and CD44+/CD24- cells represent a population that correlates with human breast cancer stem cells.
Journal ArticleDOI
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance
Jean-Pierre Gillet,Anna Maria Calcagno,Sudhir Varma,Miguel Marino,Lisa J. Green,Meena I. Vora,Chirayu Patel,Josiah N. Orina,Tatiana Eliseeva,Vineet Singal,Raji Padmanabhan,Ben Davidson,Ram Ganapathi,Anil K. Sood,Bo R. Rueda,Suresh V. Ambudkar,Michael M. Gottesman +16 more
TL;DR: The necessity for new in vitro cancer models and the use of primary tumor models in which gene expression can be manipulated and small molecules tested in a setting that more closely mimics the in vivo cancer microenvironment is emphasized so as to avoid radical changes in gene expression profiles brought on by extended periods of cell culture.
Journal ArticleDOI
Prolonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics
Anna Maria Calcagno,Crystal D. Salcido,Jean-Pierre Gillet,Chung-Pu Wu,Jennifer Fostel,Melanie D. Mumau,Michael M. Gottesman,Lyuba Varticovski,Suresh V. Ambudkar +8 more
TL;DR: The cell population with cancer stem cell characteristics increased after prolonged continuous selection for doxorubicin resistance, and MCF-7/ADR cells were highly invasive, formed mammospheres, and were tumorigenic in mice.
Journal ArticleDOI
Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: Evaluation of current strategies
TL;DR: This review summarizes the recent advances in identifying strategies to restore sensitivity to chemotherapeutics in multidrug resistant cancer cells.