M
Michael M. Gottesman
Researcher at Laboratory of Molecular Biology
Publications - 3
Citations - 7151
Michael M. Gottesman is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: P-glycoprotein & Gene. The author has an hindex of 3, co-authored 3 publications receiving 6937 citations.
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Journal ArticleDOI
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
Franz Thiebaut,Takashi Tsuruo,Hirofumi Hamada,Michael M. Gottesman,Ira Pastan,Mark C. Willingham +5 more
TL;DR: The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract.
Journal ArticleDOI
A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity
Chava Kimchi-Sarfaty,Jung Mi Oh,In-Wha Kim,Zuben E. Sauna,Anna Maria Calcagno,Suresh V. Ambudkar,Michael M. Gottesman +6 more
TL;DR: It is hypothesized that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites.
Journal ArticleDOI
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
Chang jie Chen,Janice E. Chin,Kazumitsu Ueda,Douglas P. Clark,Ira Pastan,Michael M. Gottesman,Igor B. Roninson +6 more
TL;DR: Results are consistent with a function for P-glycoprotein as an energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.