A
Anna N. Tevyashova
Researcher at D. Mendeleev University of Chemical Technology of Russia
Publications - 41
Citations - 443
Anna N. Tevyashova is an academic researcher from D. Mendeleev University of Chemical Technology of Russia. The author has contributed to research in topics: Olivomycin & Galactomannan. The author has an hindex of 11, co-authored 38 publications receiving 310 citations. Previous affiliations of Anna N. Tevyashova include National University of Science and Technology & Hungarian Academy of Sciences.
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Journal ArticleDOI
Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group
Anna N. Tevyashova,Evgenia N Olsufyeva,Svetlana E. Solovieva,Svetlana S. Printsevskaya,M. I. Reznikova,Aleksei S. Trenin,O. A. Galatenko,Ivan D. Treshalin,E. R. Pereverzeva,Elena P. Mirchink,Elena B. Isakova,Sergey B. Zotchev,Maria N. Preobrazhenskaya +12 more
TL;DR: Compounds, namely, l-glutamate of 2-(N,N-dimethylamino)ethyl amide of S44HP (compound 2j), with high antifungal activity that were comparable in in vitro and in vivo tests to AMB and that have better toxicological properties are discovered.
Journal ArticleDOI
Formation of squaric acid amides of anthracycline antibiotics. Synthesis and cytotoxic properties
TL;DR: Of the prepared compounds, anthracycline glycoside antibiotics 1-3 with the squaric acid ester 4 was the most active on MCF-7 human mammary adenocarcinoma cells.
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Design of dual action antibiotics as an approach to search for new promising drugs
TL;DR: The review is devoted to the latest achievements in the design of dual action antibiotics ?
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New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties
Anna N. Tevyashova,Alexander M. Korolev,Trenin As,Lyubov G. Dezhenkova,Alexander A. Shtil,Vladimir I. Polshakov,Oleg Yu Savelyev,Evgenia N Olsufyeva +7 more
TL;DR: The di-modified conjugate 2-(N,N-dimethylamino)ethylamide of 3′-N-[3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanoyl] AmB showed the best combination of a high antifungal activity with a low cytotoxic and hemolytic potency.
Journal ArticleDOI
Modification of olivomycin A at the side chain of the aglycon yields the derivative with perspective antitumor characteristics
Anna N. Tevyashova,Alexander A. Shtil,Eugenia N. Olsufyeva,Yury N. Luzikov,M. I. Reznikova,Lyubov G. Dezhenkova,Elena B. Isakova,Vladimir M. Bukhman,Nikita A. Durandin,Alexander M. Vinogradov,Vladimir A. Kuzmin,Maria N. Preobrazhenskaya +11 more
TL;DR: The therapeutic effects of this derivative were achievable at tolerable concentrations, suggesting that modifications of the aglycon's side chain, namely, its shortening to methoxyacetic residue and blocking of free carboxyl group, are straightforward for the design of therapeutically applicable derivatives of olivomycin A.