A
Anna Vecchiarelli
Researcher at University of Perugia
Publications - 181
Citations - 6908
Anna Vecchiarelli is an academic researcher from University of Perugia. The author has contributed to research in topics: Candida albicans & Cryptococcus neoformans. The author has an hindex of 45, co-authored 180 publications receiving 6405 citations. Previous affiliations of Anna Vecchiarelli include Yeshiva University & Istituto Superiore di Sanità.
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Evidence for macrophage-mediated protection against lethal Candida albicans infection.
Francesco Bistoni,Anna Vecchiarelli,Elio Cenci,Paolo Puccetti,Pierfrancesco Marconi,Antonio Cassone +5 more
TL;DR: It was found that administration of PCA-2 was accompanied by an increase in the number of peripheral blood polymorphonuclear cells and by the activation in the spleen of cells with highly candidacidal activity in vitro, which conferred considerable protection against subsequent CA-6 challenge.
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Immunoregulation by capsular components of Cryptococcus neoformans.
TL;DR: The contrasting roles of GXM and MP in regulation of the immune response to C. neoformans offer a promising template for a successful approach to intervention, by scavenging GXM to attenuate its negative signals, while preserving the positive effects of MP.
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Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes.
Anna Vecchiarelli,Cinzia Retini,Donatella Pietrella,Claudia Monari,Carlo Tascini,T Beccari,Thomas R. Kozel +6 more
TL;DR: Data indicate that purified capsular polysaccharide of C. neoformans could contribute to the in vivo progress of cryptococcosis by suppressing cytokine production of macrophages and suggest that a therapeutic approach to address the suppressive effect of cryptococal poly Saccharide could be devised.
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Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.
Anna Vecchiarelli,Cinzia Retini,Claudia Monari,Carlo Tascini,Francesco Bistoni,Thomas R. Kozel +5 more
TL;DR: The results suggest a new immunosuppressive effect exerted by glucuronoxylomannan through the induction of IL-10, a potent downregulator of proinflammatory cytokines.
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An Anti-β-Glucan Monoclonal Antibody Inhibits Growth and Capsule Formation of Cryptococcus neoformans In Vitro and Exerts Therapeutic, Anticryptococcal Activity In Vivo
Anna Rachini,Donatella Pietrella,Patrizia Lupo,Antonella Torosantucci,Paola Chiani,Carla Bromuro,Carla Proietti,Francesco Bistoni,Antonio Cassone,Anna Vecchiarelli +9 more
TL;DR: It is demonstrated that cell wall β-glucan of encapsulated C. neoformans is accessible to antibodies which can exert remarkable anticryptococcal activities in vitro and in vivo.