Francesco Bistoni

TL;DR: Since BV-2 cells retain most of the morphological, phenotypical and functional properties described for freshly isolated microglial cells, it can be concluded that J2 virus infection has resulted in the immortalization of active microglia cells.

TL;DR: The data are the first demonstrating that the IL‐23/IL‐17 pathway promotes inflammation and susceptibility in an infectious disease model and modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi.

TL;DR: It is shown that a superoxide-dependent step in tryptophan metabolism along the kynurenine pathway is blocked in CGD mice with lethal pulmonary aspergillosis, leading to unrestrained Vγ1+ γδ T-cell reactivity, dominant production of interleukin (IL)-17, defective regulatory T- cell activity and acute inflammatory lung injury.

TL;DR: It is shown that reverse signaling through GITRL after engagement by soluble GITR initiates the immunoregulatory pathway of tryptophan catabolism in mouse plasmacytoid dendritic cells, by means of noncanonical NF-κB–dependent induction of indoleamine 2,3-dioxygenase (IDO).

TL;DR: In this paper, the role of interleukin (IL)6 in Candida albicans infection was defined and IL-6 deficient mice were assessed for susceptibility to systemic or gastrointestinal infection, as well as for parameters of elicited T helper cell immunity.