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Annalisa Tirella
Researcher at Manchester Academic Health Science Centre
Publications - 51
Citations - 1485
Annalisa Tirella is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Self-healing hydrogels & Cancer. The author has an hindex of 19, co-authored 43 publications receiving 1130 citations. Previous affiliations of Annalisa Tirella include RMIT University & National Research Council.
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Correction: Corrigendum: Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation
TL;DR: The results show that both stiffness and HA contribute to directing PDPC osteogenic differentiation, highlighting the role of stiffness in triggering the expression of osteogenic genes and of HA in accelerating the process, particularly at high concentrations.
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Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery
Enrique Lallana,Julio M. Rios de la Rosa,Annalisa Tirella,Maria Pelliccia,Arianna Gennari,Ian J. Stratford,Sanyogitta Puri,Marianne Ashford,Nicola Tirelli +8 more
TL;DR: The performance of these nonviral vectors appears difficult to predict simply on the basis of carrier- or payload-related variables, and a more holistic consideration of the journey of the nanoparticle, from cell uptake to cytosolic bioavailability of payload, is needed.
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The CD44-Mediated Uptake of Hyaluronic Acid-Based Carriers in Macrophages.
TL;DR: This study has established quantitative relationships between CD44 expression in differently polarized macrophages and the uptake of hyaluronic acid (HA)‐based materials, and validated a robust method for macrophage polarization, which sequentially uses differentiating and polarizing factors.
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A phase diagram for microfabrication of geometrically controlled hydrogel scaffolds
TL;DR: Alginate hydrogels were modeled and characterized by measuring stress-strain and creep behavior as well as viscosity as a function of sodium alginate concentration, cross-linking time and calcium ion concentration, and microfabricated into scaffolds using the pressure-assisted microsyringe.
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Riboflavin and collagen: New crosslinking methods to tailor the stiffness of hydrogels
TL;DR: It is shown that the compressive elastic modulus of collagen-based hydrogels can be tuned between 0.9 and 3.6 kPa by changing collagen concentration, irradiation with UV in the presence of riboflavin and freeze-drying.