Institution
University of Pisa
Education•Pisa, Toscana, Italy•
About: University of Pisa is a education organization based out in Pisa, Toscana, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 25835 authors who have published 73111 publications receiving 2131507 citations. The organization is also known as: Universitá degli Studi di Pisa & Universita degli Studi di Pisa.
Papers published on a yearly basis
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TL;DR: This biennial Review summarizes much of particle physics, using data from previous editions.
12,798 citations
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University of Barcelona1, University of Pisa2, University of Duisburg-Essen3, Auckland City Hospital4, University of São Paulo5, European University6, Icahn School of Medicine at Mount Sinai7, Goethe University Frankfurt8, University of Bologna9, Hannover Medical School10, University of Mainz11, Aix-Marseille University12, Université catholique de Louvain13, University of Düsseldorf14, Bayer15, Bayer Corporation16
TL;DR: In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Abstract: Background No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma. Methods In this multicenter, phase 3, double-blind, placebo-controlled trial, we randomly assigned 602 patients with advanced hepatocellular carcinoma who had not received previous systemic treatment to receive either sorafenib (at a dose of 400 mg twice daily) or placebo. Primary outcomes were overall survival and the time to symptomatic progression. Secondary outcomes included the time to radiologic progression and safety. Results At the second planned interim analysis, 321 deaths had occurred, and the study was stopped. Median overall survival was 10.7 months in the sorafenib group and 7.9 months in the placebo group (hazard ratio in the sorafenib group, 0.69; 95% confidence interval, 0.55 to 0.87; P<0.001). There was no significant difference between the two groups in the median time to symptomatic progression (4.1 months vs. 4.9 months, respectively, P=0.77). The median time to radiologic progression was 5.5 months in the sorafenib group and 2.8 months in the placebo group (P<0.001). Seven patients in the sorafenib group (2%) and two patients in the placebo group (1%) had a partial response; no patients had a complete response. Diarrhea, weight loss, hand-foot skin reaction, and hypophosphatemia were more frequent in the sorafenib group. Conclusions In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
10,074 citations
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TL;DR: In this article, a search for the Standard Model Higgs boson in proton-proton collisions with the ATLAS detector at the LHC is presented, which has a significance of 5.9 standard deviations, corresponding to a background fluctuation probability of 1.7×10−9.
9,282 citations
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TL;DR: In this paper, results from searches for the standard model Higgs boson in proton-proton collisions at 7 and 8 TeV in the CMS experiment at the LHC, using data samples corresponding to integrated luminosities of up to 5.8 standard deviations.
8,857 citations
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TL;DR: In this article, a method is presented which utilizes the calculation of the molecular electrostatic potential or the electric field at a discrete number of preselected points to evaluate the environmental effects of a solvent on the properties of a molecular system.
7,618 citations
Authors
Showing all 26250 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Yongsun Kim | 156 | 2588 | 145619 |
M. Razzano | 155 | 515 | 106357 |
Lorenzo Bianchini | 152 | 1516 | 106970 |
Andrew White | 149 | 1494 | 113874 |
Subir Sarkar | 149 | 1542 | 144614 |
Paul Jackson | 141 | 1372 | 93464 |
G. Calderini | 139 | 1734 | 102408 |
Guido Tonelli | 138 | 1458 | 97248 |
Brad Abbott | 137 | 1566 | 98604 |
Christoph Paus | 137 | 1585 | 100801 |
Georgios B. Giannakis | 137 | 1321 | 73517 |
G. Marchiori | 137 | 1590 | 94277 |
Andrea Giammanco | 135 | 1362 | 98093 |