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Anne L. Hitt
Researcher at Worcester Foundation for Biomedical Research
Publications - 12
Citations - 1176
Anne L. Hitt is an academic researcher from Worcester Foundation for Biomedical Research. The author has contributed to research in topics: Membrane protein & Actin. The author has an hindex of 9, co-authored 12 publications receiving 1165 citations. Previous affiliations of Anne L. Hitt include University of Massachusetts Medical School & University of Rochester.
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Journal ArticleDOI
Cytoskeleton--plasma membrane interactions
Elizabeth J. Luna,Anne L. Hitt +1 more
TL;DR: General organizational themes are beginning to emerge from examination of the large number of biochemical mechanisms that mediate the connections between membrane proteins and the underlying cytoskeleton, the so-called membrane skeleton.
Journal ArticleDOI
Membrane interactions with the actin cytoskeleton.
Anne L. Hitt,Elizabeth J. Luna +1 more
TL;DR: New information has been obtained about indirect actin-membrane associations through spectrin superfamily members and through proteins at the cytoplasmic surfaces of focal contacts and adherens junctions.
Journal ArticleDOI
Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium.
TL;DR: Results indicate that ponticulin is not required for cellular translocation, but apparently plays a role in cell patterning during development.
Journal ArticleDOI
Ponticulin is an atypical membrane protein.
TL;DR: Ponticulin apparently represents a new category of integral membrane proteins that consists of proteins with both a glycosyl anchor and membrane-spanning peptide domain(s).
Journal ArticleDOI
Ponticulin plays a role in the positional stabilization of pseudopods.
Damon C. Shutt,Deborah Wessels,K. Wagenknecht,Anand Chandrasekhar,Anne L. Hitt,Elizabeth J. Luna,David R. Soll +6 more
TL;DR: It is demonstrated that pseudopods formed off the substratum by wild-type cells are positionally fixed in relation to the substrate, that ponticulin is required for positional stabilization, and that the loss of ponticul and the concomitant loss of positional stability of pseudopod correlate with a decrease in the efficiency of chemotaxis.