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Annemarie Ziegler
Researcher at Universidad del Desarrollo
Publications - 27
Citations - 4329
Annemarie Ziegler is an academic researcher from Universidad del Desarrollo. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 17, co-authored 27 publications receiving 4201 citations. Previous affiliations of Annemarie Ziegler include Yale University & University of Zurich.
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Journal ArticleDOI
Sunburn and p53 in the onset of skin cancer
Annemarie Ziegler,Alan S. Jonason,David J. Leffellt,Jeffrey A. Simon,Jeffrey A. Simon,Harsh W. Sharma,Jonathan Kimmelman,Lee Remington,Tyler Jacks,Douglas E. Brash +9 more
TL;DR: Skin appears to possess a p53-dependent 'guardian-of-the-tissue' response to DNA damage which aborts precancerous cells, and if this response is reduced in a single cell by a prior p53 mutation, sunburn can select for clonal expansion of the p 53-mutated cell into the AK.
Journal ArticleDOI
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
Annemarie Ziegler,David J. Leffell,Subrahmanyam Kunala,Harsh W. Sharma,Mae R. Gailani,Jeffrey A. Simon,Alan J. Halperin,Howard P. Baden,Philip E. Shapiro,Allen E. Bale,Douglas E. Brash +10 more
TL;DR: To identify the sites in the p53 tumor suppressor gene most susceptible to carcinogenic mutation by sunlight, the entire coding region of 27 basal cell carcinomas of the skin was sequenced.
Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.
Douglas E. Brash,Annemarie Ziegler,Alan S. Jonason,Jeffrey A. Simon,Subrahmanyam Kunala,David J. Leffell +5 more
TL;DR: Skin appears to possess a p53-dependent "cellular proofreading" response to DNA damage in which precancerous cells self-destruct, if this response is reduced in a single cell by a prior p53 mutation, sunburn can thereafter select for clonal expansion of the p 53-mutated cell into an actinic keratosis.
Journal ArticleDOI
Circulating Deoxyribonucleic Acid As Prognostic Marker in Non–Small-Cell Lung Cancer Patients Undergoing Chemotherapy
Oliver Gautschi,Colette Bigosch,Barbara Huegli,Monika Jermann,Arthur Marx,Eveline Chassé,Daniel Ratschiller,Walter Weder,Markus Joerger,Daniel C. Betticher,R. Stahel,Annemarie Ziegler +11 more
TL;DR: The data demonstrate that quantification of plasma DNA is an accurate technique amenable to standardization, which might complement current methods for the prediction of patient survival and might be considered for evaluation in large prospective studies.
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Circulating DNA: a new diagnostic gold mine?
TL;DR: The present review of tumour-specific alterations in DNA recovered from plasma or serum of patients with various malignancies will describe the main areas of ongoing investigation, with particular emphasis on technical issues and available data of clinical relevance.