Anni-Maija Linden

TL;DR: These studies indicate that metabotropic glutamate receptors are interesting new targets to treat anxiety disorders in humans.

TL;DR: It is demonstrated that TASK-1 channels contribute to the properties of IK(SO) in adult CGNs, however, TAS k2P channel subunit composition does not alter the resting excitability of C GNs but does influence sensitivity to endogenous modulators such as Zn2+ and H+.

TL;DR: The activation of bothmGlu2 and mGlu3 receptors by LY354740 appears to be required for anxiolytic-like activity in the EPM test in mice, and these studies serve as a foundation for additional studies on underlying circuits, brain structures, and receptor subtypes involved in the anxiety-related actions of mGLU receptor active agents, and the design of future drugs for anxiety disorders in humans.

TL;DR: The suppression of fear-evoked neuronal activity in the hippocampus and drug-induced increases in neuronal activation in the CeL have been previously linked to the anxiolytic effects of clinically effective drugs such as benzodiazepines, and thus may contribute to anxioleytic actions of LY354740 in animal models and human anxiety patients.

TL;DR: Both methylone and mephedrone appeared to have a long-term effect on either behavioral or biochemical gauges of neurotoxicity in rodents.