Annie M. Welsh

TL;DR: NSC grafts can show substantial neuronal differentiation in the normal and injured adult spinal cord with good potential of integration into host neural circuits, disputes the notion of a spinal cord that is constitutively unfavorable to neuronal repair.

TL;DR: NSC grafts can survive well in a neurodegenerative environment and exert powerful clinical effects; at least a portion of these effects may be related to the ability of these grafts to express and release motor neuron growth factors delivered to host motor neurons via graft-host connections.

TL;DR: Combined immunosuppression promotes the survival of human NSCs grafted in the spinal cord of SOD1‐G93A mice and, in doing so, allows the differentiation of N SCs into neurons and leads to the improvement of key parameters of motor neuron disease.

TL;DR: The results show that NSCs might not only play a critical supportive role in repairing axonal injury in the adult spinal cord but also can be used as probes for exploring the molecular underpinnings of the regenerative potential of the mature nervous system after injury.

TL;DR: The findings suggest that antidepressants may exert very selective structural effects on their cognate monoamine systems in normal animals and raise the possibility that neurotrophic mechanisms may play a role in their clinical efficacy.