A
Anthony J. Hunt
Researcher at Repligen Corporation
Publications - 4
Citations - 1002
Anthony J. Hunt is an academic researcher from Repligen Corporation. The author has contributed to research in topics: Endothelial stem cell & Platelet factor 4. The author has an hindex of 4, co-authored 4 publications receiving 991 citations.
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Journal ArticleDOI
Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides.
Theodore E. Maione,Gary S. Gray,Joan Petro,Anthony J. Hunt,Amy L. Donner,Susan I. Bauer,Helen F. Carson,Richard J. Sharpe,Richard J. Sharpe +8 more
TL;DR: Recombinant human platelet factor-4 (rhPF4), purified from Escherichia coli, inhibited blood vessel proliferation in the chicken chorioallantoic membrane in a dose-dependent manner and suggested that the angiostatic effect was due to specific inhibition of growth factor-stimulated endothelial cell proliferation.
Journal Article
Inhibition of Tumor Growth in Mice by an Analogue of Platelet Factor 4 That Lacks Affinity for Heparin and Retains Potent Angiostatic Activity
TL;DR: The present findings support the conclusion that both r PF4 and rPF4-241 inhibit tumor growth by suppression of tumor-induced neovascularization and suggest that PF4 may play a more specific role in modulation of blood vessel development than previously recognized.
Journal ArticleDOI
Molten globule monomer to condensed dimer: role of disulfide bonds in platelet factor-4 folding and subunit association.
Kevin H. Mayo,Sharon Barker,Michael J. Kuranda,Anthony J. Hunt,Jill A. Myers,Theodore E. Maione +5 more
TL;DR: The reduced PF4 folding transition is thermodynamically linked with dimer formation which stabilizes tertiary structure and yields NMR and CD data consistent with preservation of tertiary structural folds found for the native species.
Journal ArticleDOI
Expression and purification of active recombinant platelet factor 4 from a cleavable fusion protein.
Jill A. Myers,Gary S. Gray,David J. Peters,Raymond Grimaila,Anthony J. Hunt,Theodore E. Maione,W. Thomas Mueller +6 more
TL;DR: The recombinant hPF4 (rhPF4) is tetrameric under physiological conditions, binds heparin, and inhibits angiogenesis, and could be applied to other recombinant fusion proteins.