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Anthony P. Adamis
Researcher at Genentech
Publications - 188
Citations - 32633
Anthony P. Adamis is an academic researcher from Genentech. The author has contributed to research in topics: Vascular endothelial growth factor & Vascular endothelial growth factor A. The author has an hindex of 85, co-authored 186 publications receiving 30697 citations. Previous affiliations of Anthony P. Adamis include Massachusetts Eye and Ear Infirmary & Boston Children's Hospital.
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Journal ArticleDOI
Pegaptanib for Neovascular Age-Related Macular Degeneration
TL;DR: Pegaptanib, an anti-vascular endothelial growth factor therapy, was evaluated in the treatment of neovascular age-related macular degeneration.
Journal ArticleDOI
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
Eugene W. M. Ng,David T. Shima,Perry Calias,Emmett T. Cunningham,David R. Guyer,Anthony P. Adamis +5 more
TL;DR: Pegaptanib was shown in clinical trials to be effective in treating choroidal neovascularization associated with age-related macular degeneration and has the notable distinction of being the first aptamer therapeutic approved for use in humans, paving the way for future aptamer applications.
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Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy
Anthony P. Adamis,Anthony P. Adamis,Joan W. Miller,Maria-Teresa Bernal,Donald J. D'Amico,Judah Folkman,Tet-Kin Yeo,Kiang-Teck J. Yeo +7 more
TL;DR: The vitreous levels of the angiogenic polypeptide vascular endothelial growth factor were measured and compared in eyes with and without proliferative diabetic retinopathy, and these data are consistent with vascular endothelium growth factor serving as a physiologically relevantAngiogenic factor in proliferative diabetes Retinopathy.
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A central role for inflammation in the pathogenesis of diabetic retinopathy
Antonia M. Joussen,Vassiliki Poulaki,Minh Ly Le,Kan Koizumi,Christina Esser,Hanna Janicki,Ulrich Schraermeyer,Norbert Kociok,Sascha Fauser,Bernd Kirchhof,Timothy S. Kern,Anthony P. Adamis +11 more
TL;DR: It is shown that chronic, low‐grade subclinical inflammation is responsible for many of the signature vascular lesions of diabetic retinopathy, highlighting the central and causal role of adherent leukocytes in the pathogenesis of diabetes.
Journal ArticleDOI
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies.
Jayakrishna Ambati,Jayakrishna Ambati,Balamurali K. Ambati,Balamurali K. Ambati,Sonia H Yoo,Sonia H Yoo,Sean Ianchulev,Anthony P. Adamis +7 more
TL;DR: Transgenic and knockout studies have provided important mechanistic insights into the development of choroidal neovascularization, the principal cause of vision loss in age-related macular degeneration, and this in turn has culminated in preclinical and clinical trials of directed molecular interventions.