T
Timothy S. Kern
Researcher at University of California, Irvine
Publications - 242
Citations - 20970
Timothy S. Kern is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Diabetic retinopathy & Retinal. The author has an hindex of 70, co-authored 232 publications receiving 19071 citations. Previous affiliations of Timothy S. Kern include Veterans Health Administration & Case Western Reserve University.
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Journal ArticleDOI
A central role for inflammation in the pathogenesis of diabetic retinopathy
Antonia M. Joussen,Vassiliki Poulaki,Minh Ly Le,Kan Koizumi,Christina Esser,Hanna Janicki,Ulrich Schraermeyer,Norbert Kociok,Sascha Fauser,Bernd Kirchhof,Timothy S. Kern,Anthony P. Adamis +11 more
TL;DR: It is shown that chronic, low‐grade subclinical inflammation is responsible for many of the signature vascular lesions of diabetic retinopathy, highlighting the central and causal role of adherent leukocytes in the pathogenesis of diabetes.
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Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor
Hidehiro Ishii,Michael R. Jirousek,Daisuke Koya,Chikako Takagi,Pu Xia,Allen C. Clermont,Sven-Erik Bursell,Timothy S. Kern,Lawrence M. Ballas,William Francis Heath,Stramm Lawrence E,Edward P. Feener,George L. King +12 more
TL;DR: When administered orally, LY333531 ameliorated the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats in a dose-responsive manner, in parallel with its inhibition of PKC activities.
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Inflammation in diabetic retinopathy.
TL;DR: The inflammatory mediators and their relationship to early and late DR are reviewed, and the potential of anti-inflammatory approaches to inhibit development of different stages of the retinopathy is discussed.
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Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy.
TL;DR: Findings indicate that diabetes and galactosemia lead to accelerated death in situ of both retinal pericytes and endothelial cells; the event is specific for vascular cells; it precedes histological evidence of retinopathy; and it can be induced by isolated hyperhexosemia.
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Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic Retinopathy
TL;DR: This new hypothesis offers new insight into the pathogenesis of diabetic retinopathy, and offers novel targets to inhibit the ocular disease.