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Antonella De Angelis
Researcher at Seconda Università degli Studi di Napoli
Publications - 91
Citations - 6478
Antonella De Angelis is an academic researcher from Seconda Università degli Studi di Napoli. The author has contributed to research in topics: Medicine & Heart failure. The author has an hindex of 27, co-authored 71 publications receiving 5610 citations. Previous affiliations of Antonella De Angelis include Sapienza University of Rome & Brigham and Women's Hospital.
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Journal ArticleDOI
Human cardiac stem cells
Claudia Bearzi,Marcello Rota,Toru Hosoda,Jochen Tillmanns,Angelo Nascimbene,Antonella De Angelis,Saori Yasuzawa-Amano,Irina Trofimova,Robert W. Siggins,Nicole LeCapitaine,Stefano Cascapera,Antonio Paolo Beltrami,David A. D'Alessandro,Elias Zias,Federico Quaini,Konrad Urbanek,Robert E. Michler,Roberto Bolli,Jan Kajstura,Annarosa Leri,Piero Anversa +20 more
TL;DR: The identification in vitro of a class of human c-kit-positive cardiac cells that possess the fundamental properties of stem cells: they are self-renewing, clonogenic, and multipotent is reported.
Journal ArticleDOI
Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure
Konrad Urbanek,Daniele Torella,Farooq Sheikh,Antonella De Angelis,Daria Nurzynska,Furio Silvestri,C. Alberto Beltrami,Rossana Bussani,Antonio Paolo Beltrami,Federico Quaini,Roberto Bolli,Annarosa Leri,Jan Kajstura,Piero Anversa +13 more
TL;DR: The human heart possesses a CSC compartment, and CSC activation occurs in response to ischemic injury, and the loss of functionally competent CSCs in chronic ischeMIC cardiomyopathy may underlie the progressive functional deterioration and the onset of terminal failure.
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Cardiac Stem Cells Possess Growth Factor-Receptor Systems That After Activation Regenerate the Infarcted Myocardium, Improving Ventricular Function and Long-Term Survival
Konrad Urbanek,Marcello Rota,Stefano Cascapera,Claudia Bearzi,Angelo Nascimbene,Antonella De Angelis,Toru Hosoda,Stefano Chimenti,Mathue Baker,Federica Limana,Daria Nurzynska,Daniele Torella,Francesco Rotatori,Raffaella Rastaldo,Ezio Musso,Federico Quaini,Annarosa Leri,Jan Kajstura,Piero Anversa +18 more
TL;DR: The heart has an endogenous reserve of CSCs-ECCs that can be activated to reconstitute dead myocardium and recover cardiac function and induced increased survival and rescued animals with infarcts that were up to 86% of the ventricle, which are commonly fatal.
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Stem cell niches in the adult mouse heart
Konrad Urbanek,Daniela Cesselli,Marcello Rota,Angelo Nascimbene,Antonella De Angelis,Toru Hosoda,Claudia Bearzi,Alessandro Boni,Roberto Bolli,Jan Kajstura,Piero Anversa,Annarosa Leri +11 more
TL;DR: The recognition of long-term label-retaining cells provides functional evidence of resident CSCs in the myocardium, indicating that the heart is an organ regulated by a stem cell compartment.
Journal ArticleDOI
Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene
Marcello Rota,Nicole LeCapitaine,Toru Hosoda,Alessandro Boni,Antonella De Angelis,Maria Elena Padin-Iruegas,Grazia Esposito,Serena Vitale,Konrad Urbanek,Claudia Casarsa,Marco Giorgio,Thomas F. Lüscher,Pier Giuseppe Pelicci,Piero Anversa,Annarosa Leri,Jan Kajstura +15 more
TL;DR: In a model of insulin-dependent diabetes mellitus, the generation of reactive oxygen species (ROS) leads to telomeric shortening, expression of the senescent associated proteins p53 and p16INK4a, and apoptosis of CPCs, impairing the growth reserve of the heart, suggesting that intact CPCs can effectively counteract the impact of uncontrolled diabetes on the heart.