Antonella Mannini

TL;DR: Electrical signals elicited by integrin interaction with ECM components and their role in neurite outgrowth were studied in two clones isolated from 41A3 murine neuroblastoma cell line, revealing a similar implication of integrins in the adhesion of these clones to the ECM proteins.

TL;DR: The data point to a cooperation between tumor cells and macrophages elicited by tumor cells themselves in generating key enzymes essential in the promotion of tumor invasiveness, such as uPAR and MMP-9.

TL;DR: The results of in vivo and in vitro studies suggest that COX-2 expressed in TAMs appears to act as an effective biomarker of melanoma progression, and melanoma cells themselves might stimulate COx-2 in macrophages.

TL;DR: A particularly high level of ether-linked lipids was found in high metastatic variants isolated from murine melanoma and fibrosarcoma lines, as well as in human mammary carcinomas, which has possible relevance to the invasive properties of metastatic cells.

TL;DR: The notion that macrophages at different states of activation may enhance lung colonization of tumor cells by inducing a partially stable change of phenotype is supported.