L
Lido Calorini
Researcher at University of Florence
Publications - 105
Citations - 3802
Lido Calorini is an academic researcher from University of Florence. The author has contributed to research in topics: Melanoma & Tumor progression. The author has an hindex of 33, co-authored 99 publications receiving 3142 citations. Previous affiliations of Lido Calorini include Tufts University & Tufts Medical Center.
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Journal ArticleDOI
Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness
Elisa Giannoni,Francesca Bianchini,Lorenzo Masieri,Sergio Serni,Eugenio Torre,Lido Calorini,Paola Chiarugi +6 more
TL;DR: The paracrine interplay between CAFs and cancer cells leads to an EMT-driven gain of cancer stem cell properties associated with aggressiveness and metastatic spread.
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Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.
TL;DR: It is demonstrated that CAFs induce EMT and stemness through a proinflammatory signature, which exploits reactive oxygen species to drive a migratory and aggressive phenotype of prostate carcinoma cells.
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Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy
TL;DR: This review addresses some of the most experimental evidences providing that acidity of tumor environment facilitates local invasiveness and metastatic dissemination, independently from hypoxia, with which acidity is often but not always associated.
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EphA2 Reexpression Prompts Invasion of Melanoma Cells Shifting from Mesenchymal to Amoeboid-like Motility Style
TL;DR: It is suggested that, among the redundant mechanisms operating in tumor cells to penetrate the anatomic barriers of host tissues, EphA2 plays a pivotal role in the adaptive switch in migration pattern and mechanism, defining and distinguishing tumor cell invasion strategies.
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HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells.
Giuseppina Comito,Maura Calvani,Elisa Giannoni,Francesca Bianchini,Lido Calorini,Eugenio Torre,Cristina Migliore,Silvia Giordano,Paola Chiarugi +8 more
TL;DR: It is proposed that hypoxia-driven ROS act as a primary driving force to elicit an invasive program exploited by aggressive melanoma cells to escape from a hypoxic hostile environment.