Antonio Miralles

TL;DR: It is demonstrated that I2-imidazoline sites (labeled by [3H]idazoxan) and alpha-2 adrenoceptors are different pharmacological entities with similar characteristics in the human and rat brains.

TL;DR: The fact that melatonin and resveratrol are present in various foods, exhibiting possible synergistic effects, suggests the use of dietary ingredients to promote health and longevity.

TL;DR: Melatonin seems to be a mitochondria-targeted antioxidant and has similar protective actions as the synthetic antioxidants, which may make it a potent protector against a variety of free radical-related diseases.

TL;DR: Although G protein alpha-subunits were able to bind to lipid bilayers, the presence of nonlamellar-prone phospholipids (phosphatidylethanolamines) enhanced their binding to model membranes, indicating that it could constitute a general mode of protein-lipid interactions, relevant in the activity and translocation of some peripheral (amphitropic) proteins from soluble to particulate compartments.

TL;DR: The positive effects of polyphenols on the prevention of the changes that occur during aging in the brain and their consequences on cognition are described, emphasizing the possible modulation of inflammaging bypolyphenols through a SIRT1-mediated mechanism.