Data Mining - Concepts and Techniques.

The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

International Journal of Computer and Applications

IEEE Transactions on Pattern Analysis and Machine Intelligence

Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. The pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by NF-κB, Akt, and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and angiogenic pathways. Curcumin is a free radical scavenger and hydrogen donor, and exhibits both pro- and antioxidant activity. It also binds metals, particularly iron and copper, and can function as an iron chelator. Curcumin is remarkably non-toxic and exhibits limited bioavailability. Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimer’s disease.

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Curcumin: From ancient medicine to current clinical trials

There are several studies that assess the influence of factors on citizens' intention to adopt e-government services in various contexts. However, there is a lack of research that examines the perceived barriers to B2G e-commerce adoption and develops an understanding of cause and effect group variables among them. This research is the first of its kind to extensively review the relevant literature in e-commerce adoption and assess the selected key factors which are equally relevant in the B2G e-commerce adoption. The authors apply a unique multi-criteria decision-making technique called DEMATEL to understand the nature of the barriers and collect data from eight experts having experience in B2G procurement in the public sector and government organizations. The data findings revealed that out of nine selected variables, five (i.e., lack of IT infrastructure [B1], lack of expertise and technical skills [B2], high cost of technology [B3], perceived information security risk [B5], and lack of awareness of government issues and legal policies [B6]) belonged to the ‘cause group' whereas the remaining four (i.e., organisational resistance to change [B4], lack of top management support [B7], low perceived operational benefits [B8], and unwillingness to adopt B2G e-commerce services [B9]) were found to be part of ‘effect group'. The theoretical and practical implications of the current study may enhance the understanding of B2G e-commerce adoption.

https://www.igi-global.com/ViewTitle.aspx?TitleId=323571&isxn=9781668479087

Perceived Barriers to Business-to-Government (B2G) E-Commerce Adoption

Magnetic bead purification of enveloped alphavirus and flavivirus

We report a case of 11 year old young girl referred with complaint of right sided photophobia and pain following faucet induced trauma to left eye 3 months ago, followed by loss of sight in left eye. Patient presented to us with prepthisical left eye and anterior segment uveitis in right eye. Fundus picture revealed cream colour white nodules confirmed as Dalen Fuchs on fundus fluorescein angiography and presence of hypereflective lesions placed at level of retinal pigment epithelium with disruption of the inner and outer segment (IS/OS) junction on spectral domain optical coherence tomography. Ultrasonogram-B-scan confirmed closed funnel retinal detachment in traumatized left eye and increased choroidal thickness in sympathizing right eye. She underwent orbital computerized axial tomography scan to rule out intraocular foreign body. She was diagnosed as a case of delayed sympathetic ophthalmia. Subsequently she was put on intensive topical with oral steroids and immunesuppressive therapy constituted with oral azathioprine and methotrexate continued for one year and tapered on resolution of presenting signs. At final follow up sympathizing eye was quiescent and sympathetic eye was prepthisical. Sympathetic ophthalmia needs to be distinguished from other ocular auto-immune disorder such as Vogt Koyanagi Harada disease and Acute Multifocal Pigment Placoid Epitheliopathy to which it bears striking resemblance. As these disorders have variable response to treatment with widely differing outcome one must keep that in view while managing them. It is important to remember as the treatment is prolonged recurrences and patient drop outs are commonly noted. 

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Delayed Sympathetic Ophthalmia Involving Posterior Segment a Dilemma: A Case Report

The thiazepine carboxamides (VI) are obtained by a two-step diversity oriented synthetic method including the copper-catalyzed synthesis of dibenzothiazepine as first step followed by Ugi—Joulli reaction of the obtained cyclic imines as second step.

A Sequential Synthetic Strategy Towards Unexplored Dibenzo[b,f][1,4]thiazepine Carboxamides: Copper Catalyzed C—S Cyclization Followed by Ugi Type 3CC Cascade.

A new class of calixarene linked fluorescein based emissive supramolecular compounds with broad range of columnar liquid crystalline properties, self-assembly, photophysical, DFT and bio-imaging applications.

Anuj Sharma

Papers

Perceived Barriers to Business-to-Government (B2G) E-Commerce Adoption

Magnetic bead purification of enveloped alphavirus and flavivirus

Delayed Sympathetic Ophthalmia Involving Posterior Segment a Dilemma: A Case Report

A Sequential Synthetic Strategy Towards Unexplored Dibenzo[b,f][1,4]thiazepine Carboxamides: Copper Catalyzed C—S Cyclization Followed by Ugi Type 3CC Cascade.

Fluorescein-appended calixarene-functionalized supramolecular AIE-active liquid crystalline materials for self-assembly and bio-imaging applications