Aphrodite Vasilaki

TL;DR: This work hypothesized that contracting skeletal muscle was a major source of oxidizing free radical species and that untrained skeletal muscle would adapt to the oxidative stress of a single short period of contractile activity by upregulation of the activity of cytoprotective proteins in the absence of overt cellular damage.

TL;DR: In vitamin C‐supplemented subjects, adaptive responses to oxidants are attenuated, but that this may reflect an increased baseline expression of potential protective systems against oxidative stress (SOD, catalase and HSPs).

TL;DR: Muscle mitochondria do not modulate cytosolic superoxide in skeletal muscle but NADPH oxidase is a major contributor both at rest and during contractions.

TL;DR: Contractile activity increased skeletal muscle ROS generation in both adult and old mice with no evidence for an age‐related exacerbation of ROS generation.

TL;DR: There is considerable evidence that the production of free radicals is modified during the ageing process, and the possible effects of this modification on the ability of muscle cells to respond to stress and the functional effect that this may have on their muscles as the authors age are examined.