A
Arati Sharma
Researcher at Pennsylvania State University
Publications - 64
Citations - 4300
Arati Sharma is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Melanoma & Cancer. The author has an hindex of 28, co-authored 63 publications receiving 3919 citations. Previous affiliations of Arati Sharma include Penn State Milton S. Hershey Medical Center & Penn State Cancer Institute.
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Journal ArticleDOI
Deregulated Akt3 Activity Promotes Development of Malignant Melanoma
Jill M. Stahl,Arati Sharma,Mitchell Cheung,Melissa Zimmerman,Jin Q. Cheng,Marcus Bosenberg,Mark Kester,Lakshman Sandirasegarane,Gavin P. Robertson +8 more
TL;DR: It is reported that selective activation of the Akt3 protein promotes cell survival and tumor development in 43 to 60% of nonfamilial melanomas and provides new therapeutic opportunities for patients in the advanced stages of this disease.
Journal ArticleDOI
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.
Arati Sharma,Nishit R. Trivedi,Melissa Zimmerman,David A. Tuveson,Charles D. Smith,Gavin P. Robertson +5 more
TL;DR: The mechanistic underpinnings by which mutant (V599E)B-RAF promotes melanoma development are identified and the effectiveness of targeting this protein to inhibit melanoma tumor growth is shown.
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Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development.
TL;DR: A novel model has been developed in this study showing that neutrophils regulate lung metastasis development through physical interaction and anchoring of circulating tumor cells to endothelium, and targeting IL-8 in melanoma cells has the potential to decrease metastases development by disrupting interaction with neutrophil.
Journal Article
Loss of PTEN Promotes Tumor Development in Malignant Melanoma
Jill M. Stahl,Mitchell Cheung,Arati Sharma,Nishit R. Trivedi,Sumathi Shanmugam,Gavin P. Robertson +5 more
TL;DR: Loss of PTEN reduces apoptosis and promotes cell survival, thereby favoring melanoma tumor formation and providing an etiological basis for PTEN loss during the genesis of sporadic melanomas.
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Calcium Phosphate Nanocomposite Particles for In Vitro Imaging and Encapsulated Chemotherapeutic Drug Delivery to Cancer Cells
Mark Kester,Yasser Heakal,Todd E. Fox,Arati Sharma,Gavin P. Robertson,Thomas T. Morgan,Erhan I. Altinoglu,Amra Tabaković,Mylisa R. Parette,Sarah M. Rouse,Victor Ruiz-Velasco,James H. Adair +11 more
TL;DR: Calcium phosphate nanocomposite particles (CPNPs) are reported on that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for an extended time at 37 degrees C and can efficaciously deliver hydrophobic antineoplastic agents in several cell model systems.