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Archana Belle
Researcher at University of California, San Francisco
Publications - 11
Citations - 4895
Archana Belle is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Proteome & Gene. The author has an hindex of 8, co-authored 10 publications receiving 4693 citations. Previous affiliations of Archana Belle include University at Albany, SUNY & State University of New York System.
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Journal ArticleDOI
Global analysis of protein expression in yeast
Sina Ghaemmaghami,Won-Ki Huh,Kiowa Bower,Russell W. Howson,Archana Belle,Noah Dephoure,Erin K. O'Shea,Jonathan S. Weissman +7 more
TL;DR: A Saccharomyces cerevisiae fusion library is created where each open reading frame is tagged with a high-affinity epitope and expressed from its natural chromosomal location, and it is found that about 80% of the proteome is expressed during normal growth conditions.
Journal ArticleDOI
Quantification of protein half-lives in the budding yeast proteome
TL;DR: Analysis of a simple dynamic protein production model reveals a remarkable correlation between transcriptional regulation and protein half-life within some groups of coregulated genes, suggesting that cells coordinate these two processes to achieve uniform effects on protein abundances.
Journal ArticleDOI
Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains.
Russell W. Howson,Won-Ki Huh,Sina Ghaemmaghami,James V. Falvo,Kiowa Bower,Archana Belle,Noah Dephoure,Dennis D. Wykoff,Jonathan S. Weissman,Erin K. O'Shea +9 more
TL;DR: The construction of two collections of budding yeast strains that facilitate proteome-wide measurements of protein properties and the use of the TAP collection in performing high-throughput immunoprecipitation experiments are described.
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Intronless homing: site-specific endonuclease SegF of bacteriophage T4 mediates localized marker exclusion analogous to homing endonucleases of group I introns
TL;DR: SegF, a novel site-specific DNA endonuclease encoded by gene 69, is described, which is similar to GIY-YIG homing endonucleases of group I introns, and interestingly, SegF preferentially cleaves gene 56 of T2, both in vitro and in vivo, compared with that of phage T4.
Journal ArticleDOI
Recombinant Anthrax Toxin Receptor-Fc Fusion Proteins Produced in Plants Protect Rabbits against Inhalational Anthrax
Keith L. Wycoff,Archana Belle,Dorothée Deppe,Leah Schaefer,James Maclean,Simone Haase,Anke K. Trilling,Shihui Liu,Stephen H. Leppla,Isin N. Geren,Isin N. Geren,Jennifer Pawlik,Johnny W. Peterson +12 more
TL;DR: A fusion of the extracellular domain of human CMG2 and human IgG Fc effectively neutralized, in vitro, LeTx-containing mutant forms of PA that were not neutralized by anti-PA monoclonal antibodies.