Arjun Narayanan

TL;DR: The use of sulfonyl fluoride probes in chemical biology is reviewed and three new probes are introduced that provide new insights into the mechanism behind the formation of fluoride in seawater.

TL;DR: This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes, illustrating the utility of sulfonyl fluoride probes designed to react with specific tyrosines of a protein and augments the chemical biology toolkit by these probes uses in target validation and molecular pharmacology.

TL;DR: Whereas replacing PhOCH3 with PhOCF3 is a common tactic to optimize ADME properties, the analysis suggests Ph OCF2H may be a more attractive alternative, and greater exploitation of this motif is recommended.

TL;DR: This review highlights some of the recent advances made in understanding of the diversity of tyrosine biochemistry and shows how this has inspired novel applications in numerous areas of molecular design and synthesis, including chemical biology and bioconjugation.

TL;DR: In this paper, a non-covalent modulator of HbS, PF-07059013 (23), has been developed and tested on mice with Townes SCD.