M
Ming Z. Chen
Researcher at Pfizer
Publications - 19
Citations - 461
Ming Z. Chen is an academic researcher from Pfizer. The author has contributed to research in topics: Nucleophilic addition & Regioselectivity. The author has an hindex of 9, co-authored 19 publications receiving 396 citations. Previous affiliations of Ming Z. Chen include Scripps Research Institute & University of Pennsylvania.
Papers
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Journal ArticleDOI
Regioselective Reductive Cross-Coupling Reactions of Unsymmetrical Alkynes
TL;DR: The present microreview summarizes the progress over the last few years in defining regioselective reductive cross-coupling reactions of unsymmetrical alkynes with terminal- and internal alkynes, aldehydes, and imines and discusses the challenges associated with "crossed" versions of this mode of reactivity.
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Three-Component Coupling Sequence for the Regiospecific Synthesis of Substituted Pyridines
Ming Z. Chen,Glenn C. Micalizio +1 more
TL;DR: A de novo synthesis of substituted pyridines is described that proceeds through nucleophilic addition of a dithiane anion to an α,β-unsaturated carbonyl followed by metallacycle-mediated union of the resulting allylic alcohol with preformed trimethylsilane-imines.
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Visible-Light-Driven Photocatalytic Initiation of Radical Thiol–Ene Reactions Using Bismuth Oxide
Olugbeminiyi O. Fadeyi,James J. Mousseau,Yiqing Feng,Christophe Allais,Philippe Nuhant,Ming Z. Chen,Betsy Pierce,Ralph P. Robinson +7 more
TL;DR: A nontoxic and inexpensive photocatalytic initiation of anti-Markovnikov hydrothiolation of olefins using visible light is reported, enabling a mild and selective method for radical initiation in thiol-ene reactions between a wide scope of oolefins and thiols.
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Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.
Olugbeminiyi O. Fadeyi,Mihir D. Parikh,Ming Z. Chen,Robert E. Kyne,Alexandria P. Taylor,Inish O'Doherty,Stephen E. Kaiser,Sabrina Barbas,Sherry Niessen,Manli Shi,Scott L. Weinrich,John Charles Kath,Lyn H. Jones,Ralph P. Robinson +13 more
TL;DR: The chemoselective synthesis of a toolbox of highly functionalized aryl SF monomers that are used to quickly prepare SF chemical biology probes are reported.
Journal ArticleDOI
Preparation of stereodefined homoallylic amines from the reductive cross-coupling of allylic alcohols with imines.
Ming Z. Chen,Martin McLaughlin,Masayuki Takahashi,Michael A. Tarselli,Dexi Yang,Shuhei Umemura,Glenn C. Micalizio +6 more
TL;DR: Empirical models are proposed that are consistent with the observed stereochemical course of these coupling reactions en route to chiral homoallylic amines possessing di- or trisubstituted alkenes and anti- or syn- relative stereochemistry at the allylic and homoALLYlic positions.