Arnold S. Lippa

TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.

TL;DR: This unit presents protocols for the most commonly used animal tests of anxiety, including the Geller‐Seifter conflict test, the social interaction test, light/dark exploration, the elevated plus‐maze, defensive burying, and the thirsty rat conflict.

TL;DR: This unit presents protocols for the most commonly used animal tests of anxiety, including the Geller‐Seifter conflict test, the social interaction test, light/dark exploration, the elevated plus‐maze, defensive burying, and the thirsty rat conflict.

TL;DR: KRM-II-81 is the lead compound in a new series of orally bioavailable imidazodiazepines entering IND-enabling safety studies as discussed by the authors , which has a preclinical profile predicting efficacy against pharmacoresistant epilepsy, traumatic brain injury, and neuropathic pain.

TL;DR: D5‐K RM‐II‐81, like KRM‐II-81, significantly prevented seizures induced by pentylenetetrazol when given orally and was targeted in the design of a deuterated analog that could be evaluated as a potentially longer‐acting analog.