Institution
American Cyanamid
About: American Cyanamid is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 9385 authors who have published 12251 publications receiving 224640 citations. The organization is also known as: American Cyanamid Company.
Topics: Alkyl, Catalysis, Acrylonitrile, Polymerization, Polymer
Papers published on a yearly basis
Papers
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TL;DR: The comparison of two treatments generally falls into one of the following two categories: (a) a number of replications for each of the two treatments, which are unpaired, or (b) we may have a series of paired comparisons, some of which may be positive and some negative as mentioned in this paper.
Abstract: The comparison of two treatments generally falls into one of the following two categories: (a) we may have a number of replications for each of the two treatments, which are unpaired, or (b) we may have a number of paired comparisons leading to a series of differences, some of which may be positive and some negative. The appropriate methods for testing the significance of the differences of the means in these two cases are described in most of the textbooks on statistical methods.
12,871 citations
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TL;DR: In this article, a multiple comparison procedure for comparing several treatments with a control is presented, which is based on the Multiple Comparison Procedure for Comparing Several Treatments with a Control (MCPC).
Abstract: (1955). A Multiple Comparison Procedure for Comparing Several Treatments with a Control. Journal of the American Statistical Association: Vol. 50, No. 272, pp. 1096-1121.
5,756 citations
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TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Abstract: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature. Significant cholinergic dysfunctions occur in the aged and demented central nervous system, relationships between these changes and loss of memory exist, similar memory deficits can be artificially induced by blocking cholinergic mechanisms in young subjects, and under certain tightly controlled conditions reliable memory improvements in aged subjects can be achieved after cholinergic stimulation. Conventional attempts to reduce memory impairments in clinical trials hav not been therapeutically successful, however. Possible explanations for these disappointments are given and directions for future laboratory and clinical studies are suggested.
5,318 citations
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TL;DR: In this paper, a class of incomplete three level factorial designs useful for estimating the coefficients in a second degree graduating polynomial are described and the designs either meet, or approximately meet, the criterion of rotatability and for the most part can be orthogonally blocked.
Abstract: A class of incomplete three level factorial designs useful for estimating the coefficients in a second degree graduating polynomial are described. The designs either meet, or approximately meet, the criterion of rotatability and for the most part can be orthogonally blocked. A fully worked example is included.
3,194 citations
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TL;DR: These enzymes are the major cause of bacterial resistance to b-lactam antibiotics and have been the subject of extensive microbiological, biochemical, and genetic investigations.
Abstract: A classification scheme for b-lactamases based on functional characteristics is presented. Three major groups of enzymes are defined by their substrate and inhibitor profiles: group 1 cephalosporinases that are not well inhibited by clavulanic acid; group 2 penicillinases, cephalosporinases, and broadspectrum b-lactamases that are generally inhibited by active site-directed b-lactamase inhibitors; and the group 3 metallob-lactamases that hydrolyze penicillins, cephalosporins, and carbapenems and that are poorly inhibited by almost all b-lactam-containing molecules. Functional characteristics have been correlated with molecular structure in a dendrogram for those enzymes with known amino acid sequences. b-Lactamases (EC 3.5.2.6) have been designated by the Nomenclature Committee of the International Union of Biochemistry as ‘‘enzymes hydrolysing amides, amidines and other CON bonds . . . separated on the basis of the substrate: . . . cyclic amides’’ (323). These enzymes are the major cause of bacterial resistance to b-lactam antibiotics and have been the subject of extensive microbiological, biochemical, and genetic investigations. Investigators have described more than 190 unique bacterial proteins with the ability to interact with the variety of b-lactam-containing molecules that can serve as sub-
2,563 citations
Authors
Showing all 9385 results
Name | H-index | Papers | Citations |
---|---|---|---|
James J. Collins | 151 | 669 | 89476 |
Ronald S. Duman | 126 | 420 | 68020 |
Tadashi Yamamoto | 102 | 612 | 40060 |
Tomohiro Kurosaki | 96 | 295 | 28763 |
Dan H. Moore | 95 | 452 | 31209 |
George E. P. Box | 94 | 276 | 131808 |
Harry F. Noller | 94 | 250 | 34946 |
Robert A. Weinstein | 91 | 414 | 38335 |
William S. Harris | 89 | 406 | 36935 |
Arthur J. Nozik | 84 | 266 | 34277 |
John C. Cambier | 83 | 323 | 22708 |
Xiang-Jin Meng | 81 | 308 | 23540 |
Lynn W. Enquist | 79 | 301 | 22087 |
Roger L. Williams | 75 | 188 | 22360 |
Daniel Kahne | 74 | 251 | 19780 |