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Arthur A. Like
Researcher at University of Massachusetts Medical School
Publications - 46
Citations - 4984
Arthur A. Like is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Diabetes mellitus & Insulitis. The author has an hindex of 33, co-authored 46 publications receiving 4901 citations. Previous affiliations of Arthur A. Like include Northwestern University & University of Massachusetts Amherst.
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Journal ArticleDOI
Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus.
Arthur A. Like,Aldo A. Rossini +1 more
TL;DR: Ulastructural evidence of abundant type C viruses within beta cells of treated mice suggests that streptozotocin may activate murine leukemia virus in vivo in susceptible hosts.
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Studies of streptozotocin-induced insulitis and diabetes.
TL;DR: It is suggested that multiple injections of streptozotocin induce, in susceptible hosts, the triad of direct beta cell cytotoxicity, virus induction within beta cells, and cell-mediated autoimmune reaction, which appears to induce a destructive insulitis and severe diabetes.
Journal ArticleDOI
A transplantable insulinoma in the rat.
William L. Chick,Shields Warren,Rosanna N. Chute,Arthur A. Like,Vilma Lauris,Kyle C. Kitchen +5 more
TL;DR: Removal of tumors from chronically hypoglycemic animals resulted in transient rebound hyperglycemia with plasma glucose levels above 300mg/100 ml within the first 24 hr and a gradual decline to normal levels in 2-4 days, which correlated with findings of marked atropy and degranulation of the beta cells in the pancreata of tumor-bearing animals, and with gradual return of normal light microscopic morphology following tumor removal.
Journal ArticleDOI
Immunology of insulin-dependent diabetes mellitus.
TL;DR: It is clear that the authors have learned a great deal from diabetic animals and that they have a good deal yet to teach us and an enhanced understanding of the pathogenesis of human insulin-dependent diabetes will follow and lead to preventive and curative therapies that are both safe and effective.
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Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes.
TL;DR: Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats and prevented diabetes in susceptible nondiabetic controls, strengthening the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model.