J
John P. Mordes
Researcher at University of Massachusetts Medical School
Publications - 207
Citations - 9865
John P. Mordes is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Transplantation & Diabetes mellitus. The author has an hindex of 52, co-authored 206 publications receiving 9670 citations. Previous affiliations of John P. Mordes include Harvard University & University of Massachusetts Boston.
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Journal ArticleDOI
Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
David C. Parker,Dale L. Greiner,Nancy E. Phillips,Michael C. Appel,Alan W. Steele,Fiona H. Durie,Randolph J. Noelle,John P. Mordes,Aldo A. Rossini +8 more
TL;DR: This data indicates that small lymphocytes expressing donor antigens in the absence of appropriate costimulatory signals are tolerogenic for alloreactive host cells and anti-CD40L antibody may prevent host T cells from inducing costimulations in donor lymphocytes or islet grafts.
Journal ArticleDOI
Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4
Thomas G. Markees,Nancy E. Phillips,Ethel J. Gordon,Randolph J. Noelle,Leonard D. Shultz,John P. Mordes,Dale L. Greiner,Aldo A. Rossini +7 more
TL;DR: The results suggest that, with modification, the short-term protocol may yield a procedure for the induction of long-term graft survival without prolonged immunosuppression.
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Immunology of insulin-dependent diabetes mellitus.
TL;DR: It is clear that the authors have learned a great deal from diabetic animals and that they have a good deal yet to teach us and an enhanced understanding of the pathogenesis of human insulin-dependent diabetes will follow and lead to preventive and curative therapies that are both safe and effective.
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Animal models of diabetes.
John P. Mordes,Aldo A. Rossini +1 more
TL;DR: Both the spontaneous and experimental animal models have been used effectively to study the etiologies, complications, treatments and prevention of diabetes.
Journal ArticleDOI
Requirement of the JIP1 scaffold protein for stress-induced JNK activation
Alan J. Whitmarsh,Chia-Yi Kuan,Norman J. Kennedy,Nyaya Kelkar,Tarik F. Haydar,John P. Mordes,Michael C. Appel,Aldo A. Rossini,Stephen N. Jones,Richard A. Flavell,Pasko Rakic,Roger J. Davis +11 more
TL;DR: Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro.