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Arthur C. Ley
Researcher at University of Nottingham
Publications - 43
Citations - 4622
Arthur C. Ley is an academic researcher from University of Nottingham. The author has contributed to research in topics: Kunitz domain & Ischemia. The author has an hindex of 19, co-authored 43 publications receiving 4599 citations.
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Patent
Directed evolution of novel binding proteins
Robert Charles Ladner,Sonia Kosow Guterman,Bruce L. Roberts,William Markland,Arthur C. Ley,Rachel Baribault Kent +5 more
TL;DR: In this article, a structural signal called for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) is introduced into a genetic package.
Patent
Generation and selection of novel DNA-binding proteins and polypeptides
TL;DR: In this article, a selection vector is used to reduce artifacts and a variety of methods, e.g., variegation to obtain proteins binding symmetrized forms of the half-targets and heterodimerization to obtain a protein binding the entire asymmetric target.
Patent
Serum albumin binding moieties
TL;DR: In this article, compositions comprising non-naturally occurring serum albumin binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating serum bandit molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to albumin.
Journal ArticleDOI
The distinctive separation attributes of mixed-mode resins and their application in monoclonal antibody downstream purification process.
Jie Chen,Jen Tetrault,Yanyu Zhang,Andy Wasserman,Greg Conley,Mike DiLeo,Elliot Haimes,Andrew E. Nixon,Arthur C. Ley +8 more
TL;DR: It is demonstrated that besides enhancing chromatography separation and improve product quality, especially for high molecular weight (HMW) aggregate reduction, mixed-mode resins can also help to improve process efficiency in industrial-scale mAb drug manufacturing.
Journal ArticleDOI
Iterative optimization of high-affinity proteases inhibitors using phage display. 1. Plasmin.
TL;DR: One can use selectants from one library to design target-tailored combinatorial libraries and obtain quite stable, highly specific, very high-affinity binding molecules while maintaining an essentially human framework.