Showing papers by "Arthur J. Moss published in 1995"
TL;DR: Three separate genetic loci for the long QT syndrome including mutations in two cardiac ionic channel genes were associated with different phenotypic T-wave patterns on the ECG, providing insight into the influence of genetic factors on ECG manifestations of ventricular repolarization.
Abstract: Background The long QT syndrome is an inherited disorder with prolonged ventricular repolarization and a propensity to ventricular tachyarrhythmias and sudden arrhythmic death. Recent linkage studies have demonstrated three separate loci for this disorder on chromosomes 3, 7, and 11, and specific mutated genes for long QT syndrome have been identified on two of these chromosomes. We investigated ECG T-wave patterns (phenotypes) in members of families linked to three genetically distinct forms of the long QT syndrome. Methods and Results Five quantitative ECG repolarization parameters, ie, four Bazett-corrected time intervals (QTonset-c, QTpeak-c, QTc, and Tduration-c, in milliseconds) and the absolute height of the T wave (Tamplitude, in millivolts), were measured in 153 members of six families with long QT syndrome linked to markers on chromosomes 3 (n=47), 7 (n=30), and 11 (n=76). Genotypic data were used to define each family member as being affected or unaffected with long QT syndrome. Affected member...
593 citations
TL;DR: Female first-degree relatives of patients with the long QT syndrome have a higher risk of cardiac events than male first- or second- Degree relatives, independent of recorded electrocardiographic findings.
137 citations
TL;DR: Non-visible T wave alternans can be identified automatically in high-resolution Holter recordings applying time- or frequency-domain analysis of T-wave area time series, and in LQTS pts without visible TWA, the occurrence of non- invisible TWA is directly related to QTc duration.
4 citations
TL;DR: Important variables of left ventricular ejection fraction, arrhythmias, and heart rate variability are included—factors generally not included in other studies on gender and prognosis after AMI.
Abstract: This study included important variables of left ventricular ejection fraction, arrhythmias, and heart rate variability—factors generally not included in other studies on gender and prognosis after AMI. Posthospital cardiac mortality after AMI is influenced primarily by the degree of cardiac dysfunction and known risk factors and is independent of gender.
1 citations
Book•
15 Jan 1995
1 citations
TL;DR: T wave humps are more likely to occur in individuals at young age, with longer QTc and at higher heart rates, and the diagnosis of LQTS is enhanced by identification of T waves humps for the entry ECG.
1 citations