A
Arthur Prindle
Researcher at Northwestern University
Publications - 38
Citations - 3409
Arthur Prindle is an academic researcher from Northwestern University. The author has contributed to research in topics: Population & Biofilm. The author has an hindex of 17, co-authored 34 publications receiving 2583 citations. Previous affiliations of Arthur Prindle include University of California, San Diego & Massachusetts Institute of Technology.
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Ion channels enable electrical communication in bacterial communities
TL;DR: It is shown that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially propagating waves of potassium, which result from a positive feedback loop, in which a metabolic trigger induces release of intracellular potassium which depolarizes neighbouring cells.
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Synchronized cycles of bacterial lysis for in vivo delivery
M. Omar Din,Tal Danino,Arthur Prindle,Matthew Skalak,Jangir Selimkhanov,Kaitlin Allen,Ellixis Julio,Eta Atolia,Lev S. Tsimring,Sangeeta N. Bhatia,Jeff Hasty +10 more
TL;DR: In this article, the authors used microfluidic devices to characterize the engineered lysis strain and demonstrate its potential as a drug delivery platform via co-culture with human cancer cells in vitro.
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A sensing array of radically coupled genetic ‘biopixels’
TL;DR: This work engineer the synchronization of thousands of oscillating colony ‘biopixels’ over centimetre-length scales through the use of synergistic intercellular coupling involving quorum sensing within a colony and gas-phase redox signalling between colonies.
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Metabolic co-dependence gives rise to collective oscillations within biofilms.
Jintao Liu,Arthur Prindle,Jacqueline Humphries,Marçal Gabalda-Sagarra,Munehiro Asally,Dong yeon D. Lee,San Ly,Jordi Garcia-Ojalvo,Gürol M. Süel +8 more
TL;DR: Findings indicate that oscillations support population-level conflict resolution by coordinating competing metabolic demands in space and time, suggesting new strategies to control biofilm growth.
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Programmable probiotics for detection of cancer in urine
Tal Danino,Arthur Prindle,Gabriel A. Kwong,Matthew Skalak,Howard J. Li,Kaitlin Allen,Jeff Hasty,Sangeeta N. Bhatia +7 more
TL;DR: The results demonstrate that probiotics can be programmed to safely and selectively deliver synthetic gene circuits to diseased tissue microenvironments in vivo and can noninvasively indicate the presence of liver metastasis by producing easily detectable signals in urine.