Asenath La Rue

TL;DR: The results show that insulin resistance, a prevalent and increasingly common condition in developed countries, is associated with significantly lower regional cerebral glucose metabolism, which in turn may predict worse memory performance.

TL;DR: The high percentage of WRAP participants who are carriers of APOE ε4 underscores their increased risk for developing Alzheimer’s disease, but the absence of differences related to APOE status and high mean scores on cognitive tests suggests that the APOEε4 gene has yet to have a clinical impact on cognitive functioning.

TL;DR: Insulin resistance (IR) increases Alzheimer's disease (AD) risk and is related to greater amyloid burden post‐mortem and increased deposition within areas affected by early AD.

TL;DR: It is suggested that insulin resistance in an asymptomatic, late middle–aged cohort is associated with progressive atrophy in regions affected by early Alzheimer disease and the ability to encode episodic information by negatively influencing gray matter volume in medial temporal lobe.

TL;DR: The hypothesis that brain and cognitive changes suggestive of presymptomatic LOAD may be associated with this TOMM40 polymorphism is tested.