Ashley York

TL;DR: It is shown that zinc-finger antiviral protein (ZAP) inhibited virion production by cells infected with CG-enriched HIV-1, and crosslinking–immunoprecipitation–sequencing assays demonstrated that ZAP binds directly and selectively to RNA sequences containing CG dinucleotides, suggesting that Zap exploits host CG suppression to identify non-self RNA.

TL;DR: Using mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses, the first time such a comprehensive approach has been applied to a virus, 36 novel phosphorylation sites were identified as well as confirming 3 previously-identified sites.

TL;DR: The development of an RNA-based affinity-purification strategy for the isolation of cRNPs of influenza A virus from infected cells is reported, enabling the structural and functional characterization of this elusive but essential component of the viral RNA replication machine.

TL;DR: The major mRNA nuclear export NXF1 pathway is increasingly implicated in viral mRNA export and the current understanding of how influenza A virus exploits the host mRNA export pathway for replication is discussed.

TL;DR: A role is demonstrated for the cellular phosphatase PP6 in promoting viral replication, contributing to the emerging knowledge of regulatory phosphorylation in influenza virus biology.