Trinity Zang

TL;DR: CD317 (also called BST2 or HM1), a membrane protein of previously unknown function, is identified as a tetherin andhibition of Vpu function and consequent mobilization of tetherin’s antiviral activity is a potential therapeutic strategy in HIV/AIDS.

TL;DR: An essential virus–host interaction that is conserved in two unrelated viruses is defined, where the Tsg101 is recruited by small, conserved viral sequence motifs, and agents that mimic these structures are potential inhibitors of the replication of these lethal human pathogens.

TL;DR: It is demonstrated, through mutational analyses and domain replacement experiments, that tetherin configuration rather than primary sequence is critical for antiviral activity and that infiltration of virion envelopes by one or both of tetherin's membrane anchors is necessary to tether enveloped virus particles that bud through the plasma membrane.

TL;DR: Combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV- 1-infected individuals.

TL;DR: Overall, these findings indicate that MX2 is an effector of the anti-HIV-1 activity of type-I IFN, and suggest thatMX2 inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes.