A
Aswath Balakrishnan
Researcher at Manipal University
Publications - 8
Citations - 276
Aswath Balakrishnan is an academic researcher from Manipal University. The author has contributed to research in topics: DNA methylation & Insulin resistance. The author has an hindex of 5, co-authored 7 publications receiving 189 citations. Previous affiliations of Aswath Balakrishnan include Kasturba Medical College, Manipal.
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Journal ArticleDOI
High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation
Manjunath B. Joshi,Apurva Lad,Alevoor Srinivas Bharath Prasad,Aswath Balakrishnan,L Ramachandra,Kapaettu Satyamoorthy +5 more
TL;DR: It is demonstrated that NETs are influenced by glucose homeostasis, IL‐6 is a potent inducer of energy dependent NET formation and hyperglycemia mimics a state of constitutively active pro‐inflammatory condition in neutrophils leading to reduced response to external stimuli making diabetic subjects susceptible to infections.
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Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps
Manjunath B. Joshi,Guruprasad Baipadithaya,Aswath Balakrishnan,Mangala Hegde,Manik Vohra,Rayees Ahamed,Shivashankara K. Nagri,L Ramachandra,Kapaettu Satyamoorthy +8 more
TL;DR: The data demonstrates that homocysteine can alter innate immune function by promoting NETs formation and disturbs homeostasis between platelets and neutrophils which may lead to T2D associated vascular diseases.
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Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis
TL;DR: The authors observed that IL-6-induced insulin resistance is associated with proteasomal degradation of DNA methyltransferase 1 and increased DNA synthesis, which subsequently leads to global DNA hypomethylation and differential methylation of promoters of genes involved in insulin signaling and angiogenesis.
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Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis
B. M. Shivakumar,Harish Rotti,Thanvanthri Gururajan Vasudevan,Aswath Balakrishnan,Sanjiban Chakrabarty,Ganesh Bhat,Lakshmi Rao,Cannanore Ganesh Pai,Kapaettu Satyamoorthy +8 more
TL;DR: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration.
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Evidence for perturbed metabolic patterns in bipolar disorder subjects associated with lithium responsiveness.
Manjunath B. Joshi,Supriya Pai,Aswath Balakrishnan,Manoj K. Bhat,Ananthapadmanabha Kotambail,Podila Satya Venkata Narasimha Sharma,Kapaettu Satyamoorthy +6 more
TL;DR: It is hypothesized that BD pathogenesis and lithium responsiveness is associated with impaired homeostasis of amino acid and lipid metabolism and altered metabolites enriched with key biochemical pathways associated with neuropsychiatry disorders.