M
Mangala Hegde
Researcher at Manipal University
Publications - 8
Citations - 123
Mangala Hegde is an academic researcher from Manipal University. The author has contributed to research in topics: Neutrophil extracellular traps & CD31. The author has an hindex of 3, co-authored 8 publications receiving 54 citations. Previous affiliations of Mangala Hegde include Indian Institute of Technology Guwahati.
Papers
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Journal ArticleDOI
Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps
Manjunath B. Joshi,Guruprasad Baipadithaya,Aswath Balakrishnan,Mangala Hegde,Manik Vohra,Rayees Ahamed,Shivashankara K. Nagri,L Ramachandra,Kapaettu Satyamoorthy +8 more
TL;DR: The data demonstrates that homocysteine can alter innate immune function by promoting NETs formation and disturbs homeostasis between platelets and neutrophils which may lead to T2D associated vascular diseases.
Journal ArticleDOI
Glucose induces metabolic reprogramming in neutrophils during type 2 diabetes to form constitutive extracellular traps and decreased responsiveness to lipopolysaccharides.
Manjunath B. Joshi,Rayees Ahamed,Mangala Hegde,Aswathy S. Nair,L Ramachandra,Kapaettu Satyamoorthy +5 more
TL;DR: This study provides novel insights on the metabolic reprogramming of neutrophils, which may lead to susceptibility of T2D subjects to infections.
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Interleukin-6–mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors
Mangala Hegde,Kanive Parashiva Guruprasad,L Ramachandra,Kapaettu Satyamoorthy,Manjunath B. Joshi +4 more
TL;DR: It is shown here that epigenetic mechanisms regulate the crosstalk between IL-6 and vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathways in myoepithelial and endothelial cells isolated from malignant and nonmalignant tissues of clinically characterized human breast tumors.
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Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors.
Mangala Hegde,Manjunath B. Joshi +1 more
TL;DR: In this paper, the authors provide a comprehensive understanding of key factors regulating DNMT isoforms in breast tumor pathology and documents unsolved issues, such as transcription factors, interacting proteins, hormones, cytokines and dietary elements along with their significance during pathogenesis of breast tumors.
Journal ArticleDOI
A novel bioavailable curcumin-galactomannan complex modulates the genes responsible for the development of chronic diseases in mice: A RNA sequence analysis
Kishore Banik,Elina Khatoon,Mangala Hegde,Krishan Kumar Thakur,Eswara Rao Puppala,Vegi Ganga Modi Naidu,Ajaikumar B. Kunnumakkara +6 more
TL;DR: In this paper, a self-emulsifying formulation of curcumin with fenugreek galactomannan hydrogel scaffold was used for the prevention and treatment of multiple chronic diseases.