Athol Wells

TL;DR: In patients with moderate to severe bronchiectasis, mortality is associated with a degree of restrictive and obstructive disease, poor gas transfer and chronic pseudomonas infection, which should guide future research into disease progression, and identify those patients needing intensive treatment.

TL;DR: There is good agreement between thoracic radiologists for the HRCT diagnosis of DPLD encountered in regional teaching centres, however, cases diagnosed with low confidence, particularly where NSIP is considered as a differential diagnosis, may benefit from the expertise of a reference panel.

TL;DR: Altering in mucous plugging on serial CT were associated with changes in the severity of bronchiectasis and bronchial wall thickness, and greater severity of all three morphological abnormalities at baseline CT were predictive of significant declines in forced expiratory volume.

TL;DR: CALIPER-derived variables are the strongest CT predictors of mortality in HP, and automated CT stratification is equivalent to functional indices in the ILD-GAP model for predicting outcome in HP.

TL;DR: In the empirical treatment of advanced, rapidly progressive known or suspected NSIP, i.v. cyclophosphamide is a well tolerated, rapidly acting immunosuppressant, associated with improvement or stability in most cases.