Atsushi Suzuki

TL;DR: Three specific combinations of two transcription factors, comprising Hnf4α plus Foxa1, Foxa2 or Foxa3, that can convert mouse embryonic and adult fibroblasts into cells that closely resemble hepatocytes in vitro are identified.

TL;DR: Data indicate that self-renewing pluripotent stem cells persist in the developing mouse liver and that such cells can be induced to become cells of other organs of endodermal origin under appropriate microenvironment.

TL;DR: It is demonstrated that hepatic progenitor cells are enriched by FACS and suggested approaches to supplanting organ allografting and improving artificial‐organ hepatic support are suggested.

TL;DR: The studies reveal that ICC is generated by biliary lineage cells derived from hepatocytes, rather than cholangiocytes, and found that Notch activation is critical for hepatocyte conversion into biliary dynasty cells during the onset of ICC and its subsequent malignancy and progression.

TL;DR: This work shows that Nanog expression is up-regulated in mouse ES cells by the binding of T (Brachyury) and STAT3 to an enhancer element in the mouse Nanog gene and blocks BMP-induced mesoderm differentiation ofES cells by physically interacting with Smad1 and interfering with the recruitment of coactivators to the active Smad transcriptional complexes.