Nigella sativa (N. sativa) (Family Ranunculaceae) is a widely used medicinal plant throughout the world. It is very popular in various traditional systems of medicine like Unani and Tibb, Ayurveda and Siddha. Seeds and oil have a long history of folklore usage in various systems of medicines and food. The seeds of N. sativa have been widely used in the treatment of different diseases and ailments. In Islamic literature, it is considered as one of the greatest forms of healing medicine. It has been recommended for using on regular basis in Tibb-e-Nabwi (Prophetic Medicine). It has been widely used as antihypertensive, liver tonics, diuretics, digestive, anti-diarrheal, appetite stimulant, analgesics, anti-bacterial and in skin disorders. Extensive studies on N. sativa have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective, renal protective, gastro-protective, antioxidant properties, etc. Due to its miraculous power of healing, N. sativa has got the place among the top ranked evidence based herbal medicines. This is also revealed that most of the therapeutic properties of this plant are due to the presence of thymoquinone which is major bioactive component of the essential oil. The present review is an effort to provide a detailed survey of the literature on scientific researches of pharmacognostical characteristics, chemical composition and pharmacological activities of the seeds of this plant.

A review on therapeutic potential of Nigella sativa: A miracle herb

Effect of extraction methods on yield, phytochemical constituents and antioxidant activity of Withania somnifera

Acute and chronic toxicity of Nigella sativa fixed oil.

Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds

Natural withanolides: an overview

Nigellidine ‐ A New Indazole Alkaloid from the Seeds of Nigella sativa.

Antifungal Steroidal Lactones from Withania coagulance.

Bioactive Phenolic Compounds from a Medicinal Lichen, Usnea longissima.

Two new withanolides (steroidal lactones) named coagulin F [27-hydroxy-14,20-epoxy-1-oxo-(22R)-witha-3,5,24-trienolide] (1) and coagulin G [17β,27-dihydroxy-14,20-epoxy-1-oxo-(22R)-witha-2,5,24-trienolide] (2) were isolated from the whole plant of Withania coagulans, and their structures were deduced by spectral analysis.

Two New Ergostane-Type Steroidal Lactones from Withania coagulans

Chemistry and Biology of Steroidal Alkaloids

Atta‐ur‐Rahman Atta‐ur‐Rahman

Papers

Nigellidine ‐ A New Indazole Alkaloid from the Seeds of Nigella sativa.

Antifungal Steroidal Lactones from Withania coagulance.

Bioactive Phenolic Compounds from a Medicinal Lichen, Usnea longissima.

Two New Ergostane-Type Steroidal Lactones from Withania coagulans

Chemistry and Biology of Steroidal Alkaloids