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Audrey Richter
Researcher at Southampton General Hospital
Publications - 24
Citations - 2528
Audrey Richter is an academic researcher from Southampton General Hospital. The author has contributed to research in topics: Epidermal growth factor & Growth factor. The author has an hindex of 17, co-authored 24 publications receiving 2470 citations. Previous affiliations of Audrey Richter include University of Southampton.
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Journal ArticleDOI
Involvement of the epidermal growth factor receptor in epithelial repair in asthma
Sarah M. Puddicombe,Riccardo Polosa,Audrey Richter,M T Krishna,Peter H. Howarth,Stephen T. Holgate,Donna E. Davies +6 more
TL;DR: It is found that EGF accelerated repair of scrape‐wounded monolayers and that the EGFR‐selective inhibitor, tyrphostin AG1478, inhibited both EGF‐stimulated and basal wound closure whereas dexamethasone was without effect.
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The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma
Audrey Richter,Sarah M. Puddicombe,James L. Lordan,Fabio Bucchieri,Susan J. Wilson,Ratko Djukanovic,Gordon Dent,Stephen T. Holgate,Donna E. Davies +8 more
TL;DR: Data indicate that epithelial activation by IL-13 or IL-4 plays a critical role in initiating remodeling through release of TGF-beta2, which activates the underlying myofibroblasts to secrete matrix proteins and smooth muscle and vascular mitogens to propagate remodeling changes into the submucosa.
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Asthmatic Bronchial Epithelium Is More Susceptible to Oxidant-Induced Apoptosis
Fabio Bucchieri,Sarah M. Puddicombe,James L. Lordan,Audrey Richter,Diane Buchanan,Susan J. Wilson,Jon Ward,Giovanni Zummo,Peter H. Howarth,Ratko Djukanovic,Stephen T. Holgate,Donna E. Davies +11 more
TL;DR: Cells from subjects with asthma were more susceptible to the apoptotic effects of H2O2 than cell..., and cells from normal and asthmatic bronchial epithelial cells showed no difference in their rate of proliferation or viability.
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Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease
Stefan Pierrou,Per Broberg,Rory A. O'Donnell,Krzysztof Pawłowski,Robert Virtala,Eva Lindqvist,Audrey Richter,Susan J. Wilson,Gilbert Angco,Sebastian Möller,Håkan Bergstrand,Witte Koopmann,Elisabet Wieslander,Per Erik Strömstedt,Stephen T. Holgate,Donna E. Davies,Johan Lund,Ratko Djukanovic +17 more
TL;DR: Gene set enrichment analysis showed that pathways involved in oxidant/antioxidant responses were among the most differentially expressed gene pathways in smoking individuals, with further differences seen in COPD.
Journal ArticleDOI
Cooperative Effects of Th2 Cytokines and Allergen on Normal and Asthmatic Bronchial Epithelial Cells
James L. Lordan,Fabio Bucchieri,Audrey Richter,Athanassias Konstantinidis,John W. Holloway,Matthew Thornber,Sarah M. Puddicombe,Diana Buchanan,Susan J. Wilson,Ratko Djukanovic,Stephen T. Holgate,Donna E. Davies +11 more
TL;DR: The novel finding that IL-4, IL-13, and allergen enhance release of TGF-α, a ligand for the epidermal growth factor receptor that stimulates fibroblast proliferation and goblet cell differentiation, provides a potential link between allergenic exposure, Th2 cytokines, and airway remodelling in asthma.