Auguste Sturk

TL;DR: SEC efficiently isolates extracellular vesicles with a diameter larger than 70 nm from platelet-free supernatant of platelet concentrates to improve studies on the dimensional, structural and functional properties of extraceocytes.

TL;DR: Major differences exist in the preparation of the MP samples, whether or not they are first sedimented and resuspended, means of generic MP detection, and cell lineage-specific antigenic markers, and these differences probably account for some of the different findings among the groups.

TL;DR: The increased understanding why cells release vesicle, how vesicles play a role in intercellular communication, and how vESicles may concurrently contribute to cellular homeostasis and host defense, reveals a very complex and sophisticated contribution of vesicular contribution to health and disease.

TL;DR: Elevated numbers of microparticles are encountered in patients with a great variety of diseases with vascular involvement and hypercoagulability, including disseminated intravascular coagulation, acute coronary syndromes, peripheral arterial disease, diabetes mellitus and systemic inflammatory disease.

TL;DR: More stringent isolation/separation procedures of EV and HDL are essential to know their relative contribution to the pool of circulating bioactive molecules.