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Aurora Esquela-Kerscher
Researcher at Eastern Virginia Medical School
Publications - 23
Citations - 14997
Aurora Esquela-Kerscher is an academic researcher from Eastern Virginia Medical School. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 12, co-authored 21 publications receiving 14503 citations. Previous affiliations of Aurora Esquela-Kerscher include Yale University.
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Journal ArticleDOI
The complexities of microRNA regulation: mirandering around the rules.
TL;DR: New insights into miRNA-based mechanisms and the role specific DNA- and RNA-binding factors play in fine-tuning gene expression in both negative and positive ways by directing miRNA biogenesis and activity are discussed.
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The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells.
Masaomi Kato,Trupti Paranjape,Roman-Ulrich Müller,Sunitha Nallur,Erin F. Gillespie,K Keane,Aurora Esquela-Kerscher,Aurora Esquela-Kerscher,Joanne B. Weidhaas,Frank J. Slack +9 more
TL;DR: It is confirmed that mir-34 is required for a normal cellular response to DNA damage in vivo resulting in altered cellular survival post-irradiation, and point to a potential therapeutic use for anti-miR-34 as a radiosensitizing agent in p53-mutant breast cancer.
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Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis.
TL;DR: It is found that mouse and human lin‐41 genes contain predicted conserved complementary sites for let‐7 and the lin‐4 ortholog, mir‐125, in their 3′UTRs.
Journal ArticleDOI
Post-embryonic expression of C. elegans microRNAs belonging to the lin-4 and let-7 families in the hypodermis and the reproductive system
Aurora Esquela-Kerscher,Steven M. Johnson,L. Bai,Kohta Saito,J. Partridge,Kristy L. Reinert,Frank J. Slack +6 more
TL;DR: It is found that certain lin‐4 and let‐7 family members display overlapping expression patterns in the hypodermis and the reproductive system, suggesting that combinations of miRNAs from across families may control common developmental events.
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miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration
Holly Lewis,Raymond S. Lance,Dean A. Troyer,Hind A. Beydoun,Melissa M. Hadley,Joseph Orians,Tiffany Benzine,Kenya Madric,O. John Semmes,Richard R. Drake,Aurora Esquela-Kerscher +10 more
TL;DR: The data indicates that miR-888 functions to promote prostate cancer progression and can suppress protein levels of the tumor suppressor genes RBL1 and SMAD4 and holds promise as a diagnostic tool using an innovative prostatic fluid source as well as a therapeutic target for aggressive prostate cancer.