K
Kristy L. Reinert
Researcher at Yale University
Publications - 7
Citations - 4812
Kristy L. Reinert is an academic researcher from Yale University. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 6, co-authored 7 publications receiving 4674 citations.
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Journal ArticleDOI
RAS Is Regulated by the let-7 MicroRNA Family
Steven M. Johnson,Helge Grosshans,Jaclyn Shingara,Mike Byrom,Rich Jarvis,Angie Cheng,Emmanuel Labourier,Kristy L. Reinert,David Brown,Frank J. Slack +9 more
TL;DR: It is shown that the let-7 family negatively regulates let-60/RAS, a regulatory RNAs found in multicellular eukaryotes, including humans, where they are implicated in cancer.
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The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR
TL;DR: It is demonstrated that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3'UTR, providing the first experimental evidence for an animal miRNA binding directly to its validated target in vivo.
Journal ArticleDOI
The Temporal Patterning MicroRNA let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. elegans
TL;DR: It is shown that let-7 acts in at least three tissues to regulate different transcription factors, raising the possibility of let-3 as a master temporal regulator and sequence analysis and reverse genetics to identify candidateLet-7 target genes.
Journal ArticleDOI
Architecture of a validated microRNA::target interaction.
TL;DR: It is shown that base pairing at both the 5' and 3' ends of the let-7 binding site, as well as the presence of unpaired RNA residues in the predicted duplexes, are required for lin-41 downregulation.
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Post-embryonic expression of C. elegans microRNAs belonging to the lin-4 and let-7 families in the hypodermis and the reproductive system
Aurora Esquela-Kerscher,Steven M. Johnson,L. Bai,Kohta Saito,J. Partridge,Kristy L. Reinert,Frank J. Slack +6 more
TL;DR: It is found that certain lin‐4 and let‐7 family members display overlapping expression patterns in the hypodermis and the reproductive system, suggesting that combinations of miRNAs from across families may control common developmental events.