Ayal B. Gussow

TL;DR: A comprehensive search of genomic and metagenomic databases with sensitive methods for protein sequence analysis identifies an expansive, diverse group of bacteriophages related to crAssphage and predicts the functions of the majority of phage proteins, in particular those that comprise the structural, replication and expression modules.

TL;DR: An in-depth molecular analysis is reported to reconstruct the evolutionary origins of the enhanced pathogenicity of SARS-CoV-2 and other coronaviruses that are severe human pathogens.

TL;DR: This work presents Orion, an approach that detects regions of the non-coding genome that are depleted of variation, suggesting that the regions are intolerant of mutations and subject to purifying selection in the human lineage.

TL;DR: The results highlight that the intolerance of noncoding sequence stretches in the human genome can provide a critical complementary tool to other genome annotation approaches to help identify the parts of thehuman genome increasingly likely to harbor mutations that influence risk of disease.

TL;DR: It is shown that the intolerance scores of these sub-regions significantly correlate with reported pathogenic mutations, which extends the utility of intolerance scores to indicating where pathogen mutations are mostly likely to fall within genes.