B Benacerraf

TL;DR: The results of this study provide compelling evidence for the existence of the gene or genes controlling optimal T-B-cell cooperative interactions in the designated I region of the H-2 gene complex.

TL;DR: It is suggested that the gene(s) that conditions the capability for physiologic T-B cell cooperation must be shared in common by the respective cell types, and suggest, furthermore, that this gene (or genes) belongs to the major histocompatibility system of the mouse.

TL;DR: Data indicate that antigen elicits the production of a soluble T cell product bearing both variable portion of the Ig heavy chain (VH) and I-J subregion-coded determinants which serves to communicate between T cell subsets to establish an idiotype- anti-idiotype regulatory pathway.

TL;DR: It is found that B lymphoblastoid cell lines and LPS-activated B lymphocytes can present particulate Ag up to 10(5)-fold more efficiently compared with soluble Ag and that while Ag beads are bound to the cell surface, they are internalized only rarely, suggesting there may be both surface and intracellular pathways for the presentation of particulates Ags by B cells.

TL;DR: Evidence is provided suggesting a sharing of V region structures between B- cell antibody and T- cell suppressor factor specific for an antigen (GAT) under Ir gene control, in agreement with earlier studies on T and B-cell alloreceptors, T-cell helper factors, and T andB-cell receptors for conventional antigens.