M
Martin E. Dorf
Researcher at Harvard University
Publications - 348
Citations - 17169
Martin E. Dorf is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 66, co-authored 348 publications receiving 16842 citations. Previous affiliations of Martin E. Dorf include Albert Einstein College of Medicine & National Institutes of Health.
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Journal ArticleDOI
The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness
Jose-Angel Gonzalo,Clare M. Lloyd,Danyi Wen,Juan Pablo Albar,Timothy N. C. Wells,Amanda E. I. Proudfoot,Carlos Martínez-A,Martin E. Dorf,Torbjörn Bjerke,Anthony J. Coyle,Jose-Carlos Gutierrez-Ramos +10 more
TL;DR: The results suggest that different chemokines activate different cellular and molecular pathways that in a coordinated fashion contribute to the complex pathophysiology of asthma, and that their individual blockage results in intervention at different levels of these processes.
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Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.
P R Burd,H. W. Rogers,John R. Gordon,C. A. Martin,Sundararajan Jayaraman,S D Wilson,Ann M. Dvorak,Stephen J. Galli,Martin E. Dorf +8 more
TL;DR: It is suggested that in addition to their inflammatory effector function mast cells may serve as a source of growth and regulatory factors.
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Inflammatory Chemokine Transport and Presentation in HEV: A Remote Control Mechanism for Monocyte Recruitment to Lymph Nodes in Inflamed Tissues
Roger T. Palframan,Steffen Jung,Guiying Cheng,Wolfgang Weninger,Yi Luo,Martin E. Dorf,Dan R. Littman,Barrett J. Rollins,H J Zweerink,Antal Rot,Ulrich H. von Andrian +10 more
TL;DR: It is demonstrated that inflamed peripheral tissues project their local chemokine profile to HEVs in draining LNs and thereby exert “remote control” over the composition of leukocyte populations that home to these organs from the blood.
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RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis.
Clare M. Lloyd,Andrew W M Minto,Martin E. Dorf,Amanda E. I. Proudfoot,Timothy N. C. Wells,David J. Salant,Jose-Carlos Gutierrez-Ramos +6 more
TL;DR: A novel role for MCP-1 in crescent formation and development of interstitial fibrosis is highlighted, and it is indicated that in addition to recruiting inflammatory cells this chemokine is critically involved in irreversible tissue damage.
Journal Article
A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.
TL;DR: The monoclonal antibodies produced by fusion of xenoimmune rat spleen cells with the NSI myeloma imply that Ia antigens encoded by distinct subregions share sequence homology, which may be a consequence of ancestral gene duplication.