Showing papers by "B. Brett Finlay published in 1989"
TL;DR: The degree of success of a pathogen is dependent upon the status of the host, and biochemical sensors exquisitely designed to measure and respond to such environmental stimuli and accordingly to regulate a cascade of virulence determinants essential for life within the host.
831 citations
TL;DR: The use of cultured eukaryotic cells and other model systems has facilitated the study of bacterial‐host cell interactions, and has led to a better understanding of the genetic and molecular basis of Salmonella pathogenicity.
Abstract: Salmonella species are facultative intracellular parasites, capable of penetrating (invading), surviving, and often multiplying within diverse eukaryotic cell types, including epithelial and phagocytic cells. These processes are essential for virulence, and involve both bacterial and host cell products. The use of cultured eukaryotic cells and other model systems has facilitated the study of bacterial-host cell interactions, and has led to a better understanding of the genetic and molecular basis of Salmonella pathogenicity.
195 citations