B
B. Kustermann-Kuhn
Researcher at University of Tübingen
Publications - 4
Citations - 334
B. Kustermann-Kuhn is an academic researcher from University of Tübingen. The author has contributed to research in topics: Sphingolipid Activator Proteins & Farber disease. The author has an hindex of 4, co-authored 4 publications receiving 322 citations.
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Journal ArticleDOI
Sphingolipid activator protein deficiency in a 16-week-old atypical Gaucher disease patient and his fetal sibling: biochemical signs of combined sphingolipidoses
TL;DR: A patient who presented shortly after birth with hyperkinetic behaviour, myoclonia, respiratory insufficiency and hepatosplenomegaly is described, and a unique disorder SAP deficiency is named.
Journal ArticleDOI
Additional biochemical findings in a patient and fetal sibling with a genetic defect in the sphingolipid activator protein (SAP) precursor, prosaposin. Evidence for a deficiency in SAP-1 and for a normal lysosomal neuraminidase.
TL;DR: The role of prosaposin gene products in sphingolipid metabolism was discussed in view of their biochemical findings in this genetic disorder as discussed by the authors, which indicated that, in addition to the SAP-2 deficiency, there was a defect in SAP-1 function.
Journal ArticleDOI
Sphingolipid activator protein 1 deficiency in metachromatic leucodystrophy with normal arylsulphatase A activity. A clinical, morphological, biochemical, and immunological study
W. Schlote,Klaus Harzer,H. Christomanou,Barbara C. Paton,B. Kustermann-Kuhn,B. Schmid,J. Seeger,U. Beudt,I. Schuster,U. Langenbeck +9 more
TL;DR: The results indicate that rectal biopsy morphology and lipid loading biochemistry should prove useful for the screening of SAP defects and are compared with four cases of this variant known from the literature.
Journal ArticleDOI
A case of combined Farber and Sandhoff disease.
Ch. Fusch,R. Huenges,Hugo W. Moser,A. C. Sewell,W. Roggendorf,B. Kustermann-Kuhn,Alf Poulos,W.F. Carey,Klaus Harzer +8 more
TL;DR: The effect of both enzyme deficiencies on the clinical manifestations in this patient and the genetic basis of this combination require further studies.